Table 1 Summary of Alpha-fetoprotein producing clear cell type epithelial ovarian cancer
Author | Year of publication | Age | Size | FIGO stage | Microscopic findings and immunohistochemical stain | Outcome |
|---|---|---|---|---|---|---|
Cetin et al. [1] | 2006 | 63 | 22 cm | IIIc | There were polyhedral cells with clear cytoplasm and a pleomorphic nucleus. AFP(+), EMA(+), Pancytokeratin(+) CA-125(−), CK 20(−),Vimentin(−) | Dead 70 months |
Takahashi et al. [2] | 2010 | 54 | 20 cm | IIIc | There were papillary, tubular, and cribriform growths of atypical glandular cells having pale cytoplasm, distinct cellular border and enlarged atypical nuclei with prominent nucleoli. Typical yolk sac tumor differentiation and Shiller–Duval body were absent. AFP(+) | Disease free |
Morimoto et al. [3] | 2014 | 59 | 14 cm | IIb | The presence of cuboidal or polygonal cells having a clear cytoplasmin solid nests and intermediate nuclear grade. No typical hobnail cells of conventional CCA or Schiller Duval bodies commonly observed in YST were detected. AFP(+), AE1/3(+), CEA(+), LeuM1(+), GPC3(+), Ki-67(+), SALL4(+), Calretinin(−), CD30(−), CK7(−), C-kit(−), EMA(−), HCG(−), HNF-1β(−), Inhibin-α(−), PLAP(−) | Disease free |
Present case | 2018 | 55 | 9 cm | IIIc | Polygonal, cuboidal to columnar cells with clear cytoplasm arranged in solid nests and tubule-cystic growth patterns AFP(+), CK20(+), Cdx2(+), GPC3(+), HNF-1beta(+), SALL4(+) CD30(−), CK7(−) | Dead 43 months |