Establishment and molecular characterization of a human ovarian clear cell carcinoma cell line (FDOV1)

Table 3 Cell lines of ovary clear cell carcinoma

	Cell line	Country	Age	Material	DT	Chromosome number	Transplantability	Gene characteristics
1	HUOCA-II (1987)	Japan	51	Ovary	24,28	46	Yes
2	RMG-I (1988)	Japan	34	Ascites	60	47	Yes
3	OCC1 (1990)	Hong Kong	47	Ascites	36,38	70–77	Yes
4	RMG-II (1991)	Japan	53	Ascites	58	hypertetraploid	No
5	TOV-21G(1991)^a	French-Canadian descent	62	Ovary	36	47	Yes	ARID1A p.Q758fs^a75, ARID1A p.Y551fs^a72, KRAS p.G13C, PIK3CA p.H1047Y
6	ES-2(1991)^a	Black	47	Ovary	24	66- 88	Yes	BRAF p.V600E, MAP2K1 p.D67N
7	OVISE (1995)	Japan	40	Metastatic tumor	60–70	59–65	Yes
8	OVTOKO (1995)	Japan	78	Metastatic tumor	60–70	76–83	Yes
9	JHOC-5 (1999)	Japan	47	Ovary	52	74–85	No
10	JHOC-6 (1999)	Japan	43	Recurrent tumor	70	46–49	Yes
11	SMOV-2 (1999)	Japan	46	Ovary	48.2	85–92	Yes	P53 mutation (−)
12	TAYA (2002)	Japan	43	Ascites	50	69–74	No	P53 mutation (codon 132 in exon 5), PTEN mutation(−)
13	RMG-V (2005)	Japan	52	Ascites	15.5	77–85	No
14	TU-OC-1 (2013)	Japan	65	Ovary	38.4	64–90	Yes	PIK3CA E542K mutation
15	TU-OC-2(2016)	Japan	68	Ovary	37.5	41–96	No	PIK3CA mutation (−), TP53 mutation (−) ARID1A loss
16	HCH-1 (2016)	Japan	67	Ovary	48.7, 66.4	39–44	Yes	PIK3CA mutation (−), P53 mutation(−), PTEN mutation(−), KRAS mutation(−)
17	NOCC(2016)	Japan	48	Ascites	29	60–83	Yes
18	HCH-3 (2017)	Japan	41	Ovary	82	78–87	Yes	KRAS mutation (+), TP53 mutation(+)
19	FDOV1(2017)	China mainland	67	Ovary	37.4	45–90	Yes	PIK3CA p.H1047R, ARID1A p.L2106 fs, ARID1A p.N201 fs, SPOP p.D82H ARID1B p.E1681X

^aThe biological characteristics of TOV-21G and ES-2 were obtained from ATCC database (http://www.atcc.org), and the genetic variants of TOV-21G and ES-2 were obtained from COSMIC database (https://cancer.sanger.ac.uk/cell_lines), which provide more detailed and complete genetic features of cell lines

ISSN: 1757-2215