Skip to main content

Table 4 Factors influencing the live birth rate after first embryo transfer after in vitro maturation

From: Live birth rate after human chorionic gonadotropin priming in vitro maturation in women with polycystic ovary syndrome

Predictive factors Live births
(n = 277)
No live births
(n = 596)
Univariate analysis Multivariate analysis
Odds ratio (95% CI) p-value Odds ratio (95% CI) p-value
Pretreatment factors (n = 873)b
 Age, yearsa 28.1 ± 3.5 29.1 ± 3.5 0.94 (0.90, 0.98) 0.004 0.97 (0.93, 1.02) 0.254
 Body mass index, kg/m2a 21.5 ± 2.8 22.0 ± 3.2 0.94 (0.90, 0.99) 0.019 0.95 (0.90, 1.00) 0.06
 Anti-Müllerian hormone, ng/mLa 12.5 ± 3.6 12.2 ± 3.6 1.02 (0.98, 1.06) 0.304
 Antral follicle count – n 34.3±17.9 34.4±18.5 1.00 (0.99, 1.01) 0.96
 Follicle-stimulating hormone, IU/mL 8.6 ± 1.9 8.5 ± 1.8 1.03 (0.95, 1.11) 0.524
 Progesterone, ng/mL 0.8 ± 1.9 0.7 ± 1.8 1.01 (0.93, 1.09) 0.761
 Luteinizing hormone, IU/L 14.3 ± 6.9 13.5 ± 6.7 1.02 (1.00, 1.04) 0.105   
 Free testosterone index 4.5 ± 5.6 4.6 ± 5.2 1.00 (0.97, 1.02) 0.786
 Menstrual cycles, n (%)
  Amenorrhea 15 (5.4) 33 (5.5) Ref  
  Oligomenorrhea 256 (92.4) 551 (92.4) 1.02 (0.56, 1.97) 0.946
  Regular 6 (2.2) 12 (2.0) 1.10 (0.33, 3.43) 0.871
 Polycystic ovaries on ultrasound, n (%)
  Both ovaries 228 (82.3) 488 (81.9) Ref  
  One ovary 49 (17.7) 108 (18.1) 0.97 (0.67, 1.41) 0.88
 Duration of infertility, yearsa 3.3 ± 2.3 3.8 ± 2.7 0.92 (0.86, 0.98) 0.011 0.95 (0.89, 1.02) 0.161
 Type of infertility, n (%)
  Primary 229 (82.7) 479 (80.4) Ref  
  Secondary 48 (17.3) 117 (19.6) 0.86 (0.59, 1.24) 0.419
 Number of IVF attempts, n (%)
  1 259 (93.5) 514 (86.2) Ref  
  2 11 (4.0) 64 (10.7) 0.34 (0.17, 0.63) 0.001 0.60 (0.32, 1.09) 0.105c
  3 7 (2.5) 18 (3.0) 0.77 (0.30, 1.80) 0.566
 Indications for IVM, n (%)
  Tubal factors 3 (1.1) 14 (2.3) Ref  
  Male factors 2 (0.7) 11 (1.8) 0.85 (0.10, 6.01) 0.869
  Ovulation induction failure 267 (96.4) 550 (92.3) 2.27 (0.73, 9.89) 0.202 1.92 (0.92, 4.38) 0.097
  Previous OHSS with COH 3 (1.1) 14 (2.3) 1.00 (0.16, 6.24) 0.99
  Others 2 (0.7) 7 (1.2) 1.33 (0.15, 9.99) 0.779
Treatment factors (n = 873)b
 Number of oocytes retrieveda 15.6 ± 8.4 14.7 ± 9.1 1.01 (0.99, 1.03) 0.182 0.98 (0.95, 1.01) 0.286
 Number of mature oocytes after IVMa 9.1 ± 5.0 8.5 ± 5.3 1.02 (0.99, 1.05) 0.109 0.97 (0.92, 1.02) 0.212
 Number of embryos available for transfera 6.8 ± 3.6 5.7 ± 3.6 1.09 (1.05, 1.13) < 0.001 1.14 (1.07, 1.22) < 0.001
 Mean number of embryos transferreda 2.6 ± 0.5 2.5 ± 0.6 1.55 (1.20, 2.01); 0.001   
 Number of embryos transferred, n (%)
  1 embryo transferred 2 (0.7) 34 (5.7) 0.14 (0.02, 0.47) 0.008 0.20 (0.03, 0.69) 0.032
  2 embryos transferred 104 (37.5) 247 (41.4) Ref Ref
  3 embryos transferred 171 (61.7) 315 (52.9) 1.29 (0.96, 1.73) 0.092 1.25 (0.92, 1.69) 0.152
 Embryo transfer method, n (%)
  Fresh 263 (94.9) 560 (94.0) Ref  
  Freeze-only 14 (5.1) 36 (6.0) 0.83 (0.43, 1.53) 0.56
  1. CI confidence interval, COH controlled ovarian hyperstimulation, IVF in vitro fertilization, IVM in vitro maturation, OHSS ovarian hyperstimulation syndrome
  2. aParameters analyzed as continuous variables; odds ratio values are per unit increase
  3. bThirty-three women were lost to follow-up after the first transfer, and 11 did not undergo embryo transfer, one woman had no oocytes retrieved, and three women had no embryos to transfer