Skip to main content

Table 4 Factors influencing the live birth rate after first embryo transfer after in vitro maturation

From: Live birth rate after human chorionic gonadotropin priming in vitro maturation in women with polycystic ovary syndrome

Predictive factors

Live births

(n = 277)

No live births

(n = 596)

Univariate analysis

Multivariate analysis

Odds ratio (95% CI)

p-value

Odds ratio (95% CI)

p-value

Pretreatment factors (n = 873)b

 Age, yearsa

28.1 ± 3.5

29.1 ± 3.5

0.94 (0.90, 0.98)

0.004

0.97 (0.93, 1.02)

0.254

 Body mass index, kg/m2a

21.5 ± 2.8

22.0 ± 3.2

0.94 (0.90, 0.99)

0.019

0.95 (0.90, 1.00)

0.06

 Anti-Müllerian hormone, ng/mLa

12.5 ± 3.6

12.2 ± 3.6

1.02 (0.98, 1.06)

0.304

 Antral follicle count – n

34.3±17.9

34.4±18.5

1.00 (0.99, 1.01)

0.96

 Follicle-stimulating hormone, IU/mL

8.6 ± 1.9

8.5 ± 1.8

1.03 (0.95, 1.11)

0.524

 Progesterone, ng/mL

0.8 ± 1.9

0.7 ± 1.8

1.01 (0.93, 1.09)

0.761

 Luteinizing hormone, IU/L

14.3 ± 6.9

13.5 ± 6.7

1.02 (1.00, 1.04)

0.105

  

 Free testosterone index

4.5 ± 5.6

4.6 ± 5.2

1.00 (0.97, 1.02)

0.786

 Menstrual cycles, n (%)

  Amenorrhea

15 (5.4)

33 (5.5)

Ref

 

  Oligomenorrhea

256 (92.4)

551 (92.4)

1.02 (0.56, 1.97)

0.946

  Regular

6 (2.2)

12 (2.0)

1.10 (0.33, 3.43)

0.871

 Polycystic ovaries on ultrasound, n (%)

  Both ovaries

228 (82.3)

488 (81.9)

Ref

 

  One ovary

49 (17.7)

108 (18.1)

0.97 (0.67, 1.41)

0.88

 Duration of infertility, yearsa

3.3 ± 2.3

3.8 ± 2.7

0.92 (0.86, 0.98)

0.011

0.95 (0.89, 1.02)

0.161

 Type of infertility, n (%)

  Primary

229 (82.7)

479 (80.4)

Ref

 

  Secondary

48 (17.3)

117 (19.6)

0.86 (0.59, 1.24)

0.419

 Number of IVF attempts, n (%)

  1

259 (93.5)

514 (86.2)

Ref

 

  2

11 (4.0)

64 (10.7)

0.34 (0.17, 0.63)

0.001

0.60 (0.32, 1.09)

0.105c

  3

7 (2.5)

18 (3.0)

0.77 (0.30, 1.80)

0.566

 Indications for IVM, n (%)

  Tubal factors

3 (1.1)

14 (2.3)

Ref

 

  Male factors

2 (0.7)

11 (1.8)

0.85 (0.10, 6.01)

0.869

  Ovulation induction failure

267 (96.4)

550 (92.3)

2.27 (0.73, 9.89)

0.202

1.92 (0.92, 4.38)

0.097

  Previous OHSS with COH

3 (1.1)

14 (2.3)

1.00 (0.16, 6.24)

0.99

  Others

2 (0.7)

7 (1.2)

1.33 (0.15, 9.99)

0.779

Treatment factors (n = 873)b

 Number of oocytes retrieveda

15.6 ± 8.4

14.7 ± 9.1

1.01 (0.99, 1.03)

0.182

0.98 (0.95, 1.01)

0.286

 Number of mature oocytes after IVMa

9.1 ± 5.0

8.5 ± 5.3

1.02 (0.99, 1.05)

0.109

0.97 (0.92, 1.02)

0.212

 Number of embryos available for transfera

6.8 ± 3.6

5.7 ± 3.6

1.09 (1.05, 1.13)

< 0.001

1.14 (1.07, 1.22)

< 0.001

 Mean number of embryos transferreda

2.6 ± 0.5

2.5 ± 0.6

1.55 (1.20, 2.01);

0.001

  

 Number of embryos transferred, n (%)

  1 embryo transferred

2 (0.7)

34 (5.7)

0.14 (0.02, 0.47)

0.008

0.20 (0.03, 0.69)

0.032

  2 embryos transferred

104 (37.5)

247 (41.4)

Ref

Ref

  3 embryos transferred

171 (61.7)

315 (52.9)

1.29 (0.96, 1.73)

0.092

1.25 (0.92, 1.69)

0.152

 Embryo transfer method, n (%)

  Fresh

263 (94.9)

560 (94.0)

Ref

 

  Freeze-only

14 (5.1)

36 (6.0)

0.83 (0.43, 1.53)

0.56

  1. CI confidence interval, COH controlled ovarian hyperstimulation, IVF in vitro fertilization, IVM in vitro maturation, OHSS ovarian hyperstimulation syndrome
  2. aParameters analyzed as continuous variables; odds ratio values are per unit increase
  3. bThirty-three women were lost to follow-up after the first transfer, and 11 did not undergo embryo transfer, one woman had no oocytes retrieved, and three women had no embryos to transfer