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Table 1 Previously reported cases with IVA in POI

From: Pregnancy after drug-free in vitro activation of follicles and fresh tissue autotransplantation in primary ovarian insufficiency patient: a case report and literature review

Author/year

Ref.

No. Patients

IVA technique

Patients with follicle development

Total oocytes retrieved

Pregnancies

Kawamura 2013; Suzuki 2015

[4, 16]

37

PI3K activation

PTEN

inhibition + Hippo signal disruption

9

24

3 (1 miscarriage 2 live births)

Zhai 2016

[18]

14

PI3K activation

PTEN inhibition + Hippo signal disruption

6

6

1 (1 live birth)

Our case

 

1

Hippo signal disruption only

1

2

1 (ongoing)