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Table 1 Previously reported cases with IVA in POI

From: Pregnancy after drug-free in vitro activation of follicles and fresh tissue autotransplantation in primary ovarian insufficiency patient: a case report and literature review

Author/year Ref. No. Patients IVA technique Patients with follicle development Total oocytes retrieved Pregnancies
Kawamura 2013; Suzuki 2015 [4, 16] 37 PI3K activation
PTEN
inhibition + Hippo signal disruption
9 24 3 (1 miscarriage 2 live births)
Zhai 2016 [18] 14 PI3K activation
PTEN inhibition + Hippo signal disruption
6 6 1 (1 live birth)
Our case   1 Hippo signal disruption only 1 2 1 (ongoing)