Fig. 3

Effect of progesterone (1 mg/Kg/day for 7 days) treatment to bilaterally ovariectomized mice. a, b, c, d, e, f, g. H&E stained uterine sections show a marked overcrowding of epithelial cells was noted lining the lumen suggesting hyperplasia of cells (red arrows) with high nucleo-cytoplasmic ratio and minimal cytoplasm. Small (black arrow) and slightly bigger (broken circle) spherical putative stem cells were clearly visualized. Note that despite excessive turnover of cells, mitotic figures are not visualized. Scale bar 20 μm