Reference | Study results in brief |
---|---|
Matthai et al., 2006 [13] | All 9 of 9 samples studied showed OCT-4 by RT-PCR and protein was expressed in the cytoplasm of few stromal cells. |
Forte et al., 2009 [14] | Differential expression of stemness markers (SOX2, SOX15, ERAS, SALL4, OCT4, NANOG, UTF1, DPPA2, BMI1, GDF3, ZFP42, KLF4, TCL1) were studied in endometrial and endometriotic tissue by RT-PCR. OCT-4 was detected in all the samples studied |
Bentz et al., 2010 [15] | OCT-4 expression was studied in human endometrial samples in both follicular and luteal phase. They detected mRNA in all samples (49 follicular and 40 luteal phase samples) and concluded that OCT-4 expression restricted to the cytoplasm and was not modulated by hormones. |
Pachiarotti et al., 2011 [16] | Reported nuclear OCT-4 expression in epithelial and stromal cells of both eutopic and endometriotic endometrium for the first time. They reported 10 fold higher and more intense nuclear OCT-4 expression in ectopic endometriotic tissue both in ovarian and peritoneal lesions. The group concluded that endometriosis has a stem cell origin and could lead to ovarian cancer. |
Zhou et al., 2011 [17] | Detected expression of Oct-4, Sox2 and Nanog in endometrial adenocarcinoma samples |
Chang et al., 2013 [18] | Transcription of OCT4 gene was found significantly up-regulated in human ectopic endometriotic tissues. They concluded that expression of OCT4 may contribute to the pathology of ectopic endometrial growth by stimulating the migration activity of endometrial cells. |
Song et al., 2014 [19] | Studied normal women and those with ovarian endometriosis. Sox2, Nanog and Oct-4 expression studied by qRT-PCR, Western blotting and IHC. Although they observed higher expression of Nanog and Sox2, they found a trend towards lower OCT4 mRNA and higher OCT4 protein expression in ectopic endometrium. |
Pitynski et al., 2015 [20] | Co-expression of SOX-2 and Oct4 by IHC and their correlation with clinic-pathological features of endometrial adenocarcinomas (EACs) was investigated. Reported nuclear OCT-4 and SOX2 in endometrial adenocarcinoma tissue. |
Gunjal et al., 2015 [10] | Reported pluripotent VSELs expressing nuclear OCT-4 in adult mouse endometrium for the first time. Reported regulation of stem cell markers (Oct-4A, Oct-4, Nanog, Sca-1) by circulating hormones |
Davoudi et al. 2016 [21] | mRNA expression of Oct4 and Sox2 in the uterine tissues of ovariectomized mice was regulated by hormones |
Proestling et al., 2016 [22] | Reported co-localization of SOX15 and OCT4 in epithelial and stromal cells of endometriotic tissue. Results support the hypothesis that up-regulation of stem cell-related factors contribute to the establishment of endometriotic lesions. |