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Table 2 List of publications reported OCT-4 expression in endometrial samples

From: Gonadotropin and steroid hormones regulate pluripotent very small embryonic-like stem cells in adult mouse uterine endometrium

Reference Study results in brief
Matthai et al., 2006 [13] All 9 of 9 samples studied showed OCT-4 by RT-PCR and protein was expressed in the cytoplasm of few stromal cells.
Forte et al., 2009 [14] Differential expression of stemness markers (SOX2, SOX15, ERAS, SALL4, OCT4, NANOG, UTF1, DPPA2, BMI1, GDF3, ZFP42, KLF4, TCL1) were studied in endometrial and endometriotic tissue by RT-PCR. OCT-4 was detected in all the samples studied
Bentz et al., 2010 [15] OCT-4 expression was studied in human endometrial samples in both follicular and luteal phase. They detected mRNA in all samples (49 follicular and 40 luteal phase samples) and concluded that OCT-4 expression restricted to the cytoplasm and was not modulated by hormones.
Pachiarotti et al., 2011 [16] Reported nuclear OCT-4 expression in epithelial and stromal cells of both eutopic and endometriotic endometrium for the first time. They reported 10 fold higher and more intense nuclear OCT-4 expression in ectopic endometriotic tissue both in ovarian and peritoneal lesions. The group concluded that endometriosis has a stem cell origin and could lead to ovarian cancer.
Zhou et al., 2011 [17] Detected expression of Oct-4, Sox2 and Nanog in endometrial adenocarcinoma samples
Chang et al., 2013 [18] Transcription of OCT4 gene was found significantly up-regulated in human ectopic endometriotic tissues. They concluded that expression of OCT4 may contribute to the pathology of ectopic endometrial growth by stimulating the migration activity of endometrial cells.
Song et al., 2014 [19] Studied normal women and those with ovarian endometriosis. Sox2, Nanog and Oct-4 expression studied by qRT-PCR, Western blotting and IHC. Although they observed higher expression of Nanog and Sox2, they found a trend towards lower OCT4 mRNA and higher OCT4 protein expression in ectopic endometrium.
Pitynski et al., 2015 [20] Co-expression of SOX-2 and Oct4 by IHC and their correlation with clinic-pathological features of endometrial adenocarcinomas (EACs) was investigated. Reported nuclear OCT-4 and SOX2 in endometrial adenocarcinoma tissue.
Gunjal et al., 2015 [10] Reported pluripotent VSELs expressing nuclear OCT-4 in adult mouse endometrium for the first time. Reported regulation of stem cell markers (Oct-4A, Oct-4, Nanog, Sca-1) by circulating hormones
Davoudi et al. 2016 [21] mRNA expression of Oct4 and Sox2 in the uterine tissues of ovariectomized mice was regulated by hormones
Proestling et al., 2016 [22] Reported co-localization of SOX15 and OCT4 in epithelial and stromal cells of endometriotic tissue. Results support the hypothesis that up-regulation of stem cell-related factors contribute to the establishment of endometriotic lesions.