Fig. 2

Serum miR-1290 expression is significantly elevated in HGSOC patients. (a) Relative miR-1290 expression levels in sera from healthy controls (n = 13) and EOC patients (n = 70) are shown. The average miR-1290 expression level in healthy controls was normalized to 1.0. The box-and-whisker plots indicate the median and interquartile range. (b) CA125 values in sera from healthy controls (n = 13) and EOC patients (n = 70) are shown. The box-and-whisker plots indicate the median and interquartile range. (c) ROC curves for the identification of patients with EOC (n = 70) vs. healthy controls (n = 13) based on the expression of CA125 (gray line), miR-1290 (black line), and the combination of both (dotted line). The AUC values are shown on the graphs. (d) ROC curves for the identification of patients with ovarian cancer of each histological subtype (serous: n = 30, clear-cell: n = 18, endometrioid: n = 12, mucinous: n = 10) vs. healthy controls (n = 13). (e) Relative miR-1290 expression levels in sera from healthy controls (n = 13) and HGSOC patients (n = 30) are shown. **, P < 0.01; *, P < 0.05; n.s., not significant