Fig. 2

Luteolin induced cell apoptosis and enhanced cisplatin-induced apoptosis of CAOV3/DDP cells. Cells were treated with luteolin or cisplatin or in combination for 48 h, and then the apoptosis was detected by Annexin V/PI. a Flowcytometric analysis; b Statistical analysis for apoptosis ratio in each group. Data were represented as mean ± SD of three independent experiments. * P < 0.05, ** P < 0.01, *** P < 0.001, vs. control; ## P < 0.01, ### P < 0.001 vs. cisplatin. CDDP: cisplatin. CDDP combined with luteolin (100 μM) showed a synergistic effect on the apoptosis induction of CAOV3/DDP cells (Q = 1.46 ± 0.1, > 1, P < 0.01)