Fig. 4

Luteolin inhibited cell migration and enhanced cisplatin-induced migration suppression in CAOV3/DDP cells. Migratory ability of CAOV3/DDP cells treated with increasing doses of luteolin or cisplatin or the combination of both agents was tested using wound-healing assay. a The gap of indicated groups was imaged at 0 and 48 h (magnification, × 100); b Relative migration distance of three independent experiments. * P < 0.05, *** P < 0.001, vs. control; ## P < 0.01, ### P < 0.001 vs. cisplatin. CDDP: cisplatin. CDDP combined with luteolin (10, 100 μM) showed a synergistic inhibitory effect on the migratory ability of CAOV3/DDP cells (Q = 2.91 ± 0.97 and 1.02 ± 0.003, respectively, > 1, P < 0.05 and P < 0.01, respectively)