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Fig. 5 | Journal of Ovarian Research

Fig. 5

From: Luteolin sensitizes the antitumor effect of cisplatin in drug-resistant ovarian cancer via induction of apoptosis and inhibition of cell migration and invasion

Fig. 5

Luteolin suppressed cell invasion and enhanced cisplatin-induced suppression of invasion in CAOV3/DDP cells. Invasion ability of CAOV3/DDP cells of indicated treatments was measured using Matrigel invasion assay. a The image of invaded cells (magnification,× 200); b Numbers of invaded cells in each group of three independent experiments. ** P < 0.01, *** P < 0.001, vs. control; ### P < 0.001 vs. cisplatin. CDDP: cisplatin. CDDP combined with luteolin (50, 100 μM) showed a synergistic inhibitory effect on the invasion of CAOV3/DDP cells (Q = 1.06 ± 0.02 and 1.03 ± 0.007, respectively, > 1, P < 0.05 and P < 0.01, respectively)

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