Table 2 Luteolin increased the sensitivity of CAOV3/DDP cells to cisplatin. The Q value was calculated to evaluate the effect of the combination of the two drugs. The inhibition rates were measured by CCK-8 assay. CDDP combined with luteolin (100 μM) showed a synergistic inhibitory effect on the proliferation of CAOV3/DDP cells (Q = 1.22 ± 0.04, > 1, P < 0.01). The data were expressed as the mean ± S.D. in triplicate
Drugs | Inhibition rate (%) | Q value |
|---|---|---|
Luteolin (100 μM) | 69.1 ± 0.55 | |
Luteolin (50 μM) | 42.0 ± 1.20 | |
Luteolin (10 μM) | −1.5 ± 6.26 | |
CDDP (2 μg/ml) | 30.2 ± 4.54 | |
Luteolin (100 μM) + CDDP (2 μg/ml) | 95.7 ± 0.24 | 1.22 ± 0.04 |
Luteolin (50 μM) + CDDP (2 μg/ml) | 64.3 ± 1.22 | 1.08 ± 0.06 |
Luteolin (10 μM) + CDDP (2 μg/ml) | 37.9 ± 3.02 | 1.36 ± 0.41 |