Table 3 A summary of the diagnostic power of miRNAs, conventional biomarkers, and the combination of the new and conventional markers. AUC = Area under the ROC curve. CI = Confidence Interval

CA125

0.905

0.834 - 977

<0.0001

79.41%

93.33%

HE4

0.820

0.716 - 0.923

<0.0001

77.50%

86.21%

Mir-1307

0.671

0.550 - 0.791

0.0054

33.33%

94.29%

Mir-375

0.788

0.665 - 0.890

<0.0001

61.76%

87.88%

Mir-1307+Mir-375

0.837

0.725 - 0.917

<0.0001

HE4+CA125

0.937

0.857 - 0.983

<0.0001

Mir-1307+CA125

0.959

0.873 - 0.981

<0.0001

Mir-1307+HE4

0.857

0.730 - 0.919

<0.0001

Mir-1307+CA125+HE4

0.970

0.892 - 0.997

<0.0001

Mir-375+CA125

0.940

0.870 - 0.989

<0.0001

Mir-375+HE4

0.857

0.792 - 0.960

0.0012

Mir-375+CA125+HE4

0.945

0.904 - 0.999

<0.0001