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Table 3 A summary of the diagnostic power of miRNAs, conventional biomarkers, and the combination of the new and conventional markers. AUC = Area under the ROC curve. CI = Confidence Interval

From: Upregulated expression of serum exosomal miR-375 and miR-1307 enhance the diagnostic power of CA125 for ovarian cancer

  AUC 95%CI Pvalue sensitivity% Specificity%
CA125 0.905 0.834 - 977 <0.0001 79.41% 93.33%
HE4 0.820 0.716 - 0.923 <0.0001 77.50% 86.21%
Mir-1307 0.671 0.550 - 0.791 0.0054 33.33% 94.29%
Mir-375 0.788 0.665 - 0.890 <0.0001 61.76% 87.88%
Mir-1307+Mir-375 0.837 0.725 - 0.917 <0.0001  
HE4+CA125 0.937 0.857 - 0.983 <0.0001  
Mir-1307+CA125 0.959 0.873 - 0.981 <0.0001  
Mir-1307+HE4 0.857 0.730 - 0.919 <0.0001  
Mir-1307+CA125+HE4 0.970 0.892 - 0.997 <0.0001  
Mir-375+CA125 0.940 0.870 - 0.989 <0.0001  
Mir-375+HE4 0.857 0.792 - 0.960 0.0012  
Mir-375+CA125+HE4 0.945 0.904 - 0.999 <0.0001