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Table 3 HIF-1α polymorphisms in various cancers

From: Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma

Type of cancer
(Reference No.)
Case Frequency (%) Prognosis
C1772T G1790A C1772T G1790A
OCCC (present study) 89 23.6 3.3 No association No association
Colorectal cancer (21) 336 20.6 2.7 No association No association
Colorectal cancer (22) 445 7.9 7.0 No association No association
NSCLC (13) 741 73.5 72.5 CC has longer survival than CT and TT No association
NSCLC (14) 285 46.3 47.4 TT has shorter survival than CC and CT AA has shorter survival than GG and GA
Breast cancer (15) 90 10.0 3.3 C1772T polymorphism is associated with HIF-1α
overexpression, found in patients with lymph node metastasis
No association
Breast cancer (16) 410 28.2 19.1 T allele increases risk for lymph nodes metastasis No association
Prostate cancer (18) 754 21.9 NA T allele increases risk for metastasis and resistance to ADT NA
RCC (23) 160 90.0 55.5 TT is earlier stage than the CC and CT No association
RCC (24) 620 7.7 7.3 No association No association
HNSCC (17) 52 50.0 71.2 T allele is more frequently found in patients with metastasis GA and GG have shorter survival than AA
OSCC (25) 305 7.5 7.9 No association No association
OSCC (26) 74 18.6 37.5 No association A allele has shorter survival
Thymic malignancy (27) 57 14.9 0 No association NA
Bladder cancer (19) 219 10.0 6.8 C1772T and/or G1790A polymorphic variants have shorter survival
Cervical cancer (28) 162 14.2 6.8 No association No association
Cervical cancer (29) 199 11.1 6.0 No association No association
Glioma (20) 387 70.5 75.2 CC has longer survival than CT and TT No association
  1. OCCC ovarian clear cell carcinoma, NSCLC non-small cell lung cancer, CC 1772CC genotype, CT 1772CT genotype, TT 1772TT genotype, GG 1790GG genotype, GA 1790GA genotype, AA 1790AA genotype, NA not available, RCC renal cell carcinoma, HNSCC head and neck squamous cell carcinoma, OSCC oral squamous cell carcinoma