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Table 1 Characteristics of the studies included in the meta-analysis

From: Circulating microRNAs as novel potential diagnostic biomarkers for ovarian cancer: a systematic review and updated meta-analysis

ID First Author Year Country Median age Type (Retro/Pro) Cancer Control Standard Specimen Method TNM stage (I-II/III-IV) microRNAs TN TP FN FP Cut-off Level
1 Todeschini 2017 Italy 61 Pro 168 65 Yes serum qPCR 0/168 miR-1246 50 146 15 22 0.41 high
miR-595 55 79 10 89 −0.29 high
miR-2278 43 136 22 32 0.26 high
3 miRNAs 50 141 15 27 0.41 high
2 Zuberi(a) 2016 India NA Pro 70 70 Yes serum qPCR 33/37 miR-125b 54 44 16 26 3.76 high
3 Zuberi(b) 2016 India NA Pro 70 70 Yes serum qPCR 33/37 miR-199a 67 48 3 22 4.71 high
4 Meng(a) 2016 Germany 60 Pro 163 20 Yes serum qPCR 27/118 miR-200a 18 137 2 26 NA high
miR-200b 20 86 0 77 NA high
miR-200c 20 51 0 112 NA high
3 miRNAs 18 144 2 19 NA  
5 Meng(b) 2016 Germany 56 Pro 60 32 Yes serum qPCR 8/41 miR-200a 29 40 3 20 NA high
miR-200b 29 56 3 4 NA high
miR-200c 27 51 5 9 NA high
3 miRNAs 32 50 0 10 NA  
6 Meng(c) 2015 Germany 62 Pro 180 66 Yes serum qPCR 32/147 miR-7 49 96 17 84 NA high
miR-25 42 166 24 14 NA low
miR-93 41 158 25 22 NA low
miR-429 63 107 3 73 NA high
72 66 NA 4 miRNAs 61 67 5 5 NA  
7 Gao 2015 China NA Retro 93 50 Yes serum qPCR 54/20 miR-200c 35 67 15 26 NA high
miR-141 36 64 14 29 NA high
8 Zheng 2013 China 53.75 Retro 134 70 Yes plasma qPCR 45/89 miR-205 66 40 4 94 NA high
9 Suryawanshi 2013 USA 65.52 Retro 21 20 Yes plasma qRT-PCR 3/18 miR-16, 191, and 4284 11 19 9 2 NA high
10 Hong 2013 China 58.6 Retro 96 35 Yes serum qRT-PCR 32/64 miR-221 5 85 30 11 NA high
11 Guo 2013 China 54.5 Retro 50 50 Yes serum qRT-PCR 35/15 miR-92 38 40 12 10 NA high
12 Chung 2013 Korea 57.5 Retro 18 12 Yes serum qPCR 3/14 miR-132 11 12 1 6 0.0001 low
miR-26a 9 18 0 3 0.0041 low
let-7b 12 15 3 0 0.066 low
miR-145 12 9 9 0 0.0011 low
13 Kan 2012 Australia 63 Retro 28 28 Yes serum qPCR 1/27 miR-200a 10 24 18 4 NA high
miR-200b 10 24 18 4 NA high
miR-200c 16 20 12 8 NA high
miR-200b + 200c 13 22 15 6 NA high
  1. Retro retrospective study, Pro prospective study, qPCR quantitative real-time PCR, qRT-PCR quantitative reverse transcription–PCR, TN true negatives, TP true positives, FN false negatives, FP false positives; level refers to the high or low levels of miRNA expression in blood compared with normal tissues.