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Table 2 Summary of diagnostic criteria estimates and their 95% confidence intervals (95% CIs)

From: Circulating microRNAs as novel potential diagnostic biomarkers for ovarian cancer: a systematic review and updated meta-analysis

Subgroup SEN (95%CI) SPE (95%CI) PLR (95%CI) NLR (95%CI) DOR (95%CI)
Type
 Pro 0.92 (0.89, 0.94) 0.59 (0.49, 0.68) 2.26 (1.89, 2.70) 0.10 (0.06, 0.15) 21.12 (12.83, 34.76)
 Retro 0.73 (0.65, 0.79) 0.65 (0.55, 0.74) 1.98 (1.60, 2.45) 0.32 (0.23, 0.47) 5.88 (3.73, 9.28)
Ethnicity
 Asian 0.81 (0.74, 0.86) 0.64 (0.53, 0.74) 2.23 (1.71, 2.93) 0.23 (0.15, 0.35) 9.31 (5.03, 17.23)
 Caucasian 0.89 (0.84, 0.92) 0.60 (0.51, 0.69) 2.16 (1.83, 2.55) 0.13 (0.08, 0.20) 15.28 (9.45, 24.68)
miRNA profiling
 Single miRNA 0.86 (0.81, 0.89) 0.59 (0.51, 0.66) 2.02 (1.79, 2.33) 0.17 (0.12, 0.26) 11.11 (7.55, 16.34)
 Multiple miRNA 0.90 (0.75, 0.97) 0.74 (0.59, 0.85) 3.21 (2.06, 5.01) 0.09 (0.03, 0.28) 30.06 (8.58, 105.37)
 miRNA 200 family 0.90 (0.80, 0.95) 0.58 (0.43, 0.72) 1.98 (1.61, 2.44) 0.11 (0.07, 0.17) 15.48 (7.15, 33.51)
 miRNA 200c 0.85 (0.67, 0.94) 0.52 (0.22, 0.81) 1.88 (1.17, 3.03) 0.19 (0.06, 0.57) 8.84 (3.20, 24.40)
overall 0.89 (0.84, 0.93) 0.64 (0.56, 0.72) 2.18 (1.90, 2.51) 0.15 (0.11, 0.22) 13.21 (9.00, 19.38)
  1. SEN sensitivity, SPE specificity, PLR positive likelihood ratio, NLR negative likelihood ratio, DOR diagnostic odds ratio, miRNA microRNA, Pro prospective, Retro retrospective.