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Fig. 2 | Journal of Ovarian Research

Fig. 2

From: Defining a murine ovarian cancer model for the evaluation of conditionally-replicative adenovirus (CRAd) virotherapy agents

Fig. 2

Analysis of cytopathic effects of replication competent Ad vectors. a Cytotoxic effects of wild type Ad5, Ad5-based Delta-24 and Delta-24-RGD CRAd vectors were compared in established ovarian cancer cell lines of human (SKOV3ip.1) and mouse (ID8 and ID8luc) origin using CellTox™ assayat the MOI of 100 vp/cell as compared to mock-infected cells (negative control) and completely lysed cells (positive assay control). Each data point represents the three replicate experiments ± SD (error bars are smaller than the symbols, p ≤ 0.05 *). b Monolayers of SKOV3ip.1, ID8, and ID8luc were infected with indicated Ad vectors and cell viability determined on day 6 post-infection by adding CellTiter 96 AQueous One Solution Reagent. The percentages of live cells in the monolayers exposed to replication-deficient E1-deleted Ad5∆E1 are shown as compared to wild type Ad5, Delta-24, and Delta-24-RGD-infected cells

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