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Table 1 Diagnostic performance of CA125, HE4 and combination of CA125 + HE4 in the subset of studies cited in this article

From: Biomarkers and algorithms for diagnosis of ovarian cancer: CA125, HE4, RMI and ROMA, a review

  Systematic review or meta-analysis CA125 HE4 CA125 + HE4
Se (%) (95% IC) Sp (%) (95% IC) PPV (%) NPV (%) AUC (95% IC) Se (%) (95% IC) Sp (%) (95% IC) PPV (%) NPV (%) AUC (95% IC) Se (%) (95% IC) Sp (%) (95% IC) PPV (%) NPV (%) AUC (95% IC)
Ferraro et al. [14] X 79 (77–82) 78 (76–80)     79 (76–81) 93 (92–94)     82 (78–86) 76 (72–80)    
Dikmen et al. [15]   63     0.78 78     0.93      
Chen et al. [19]   93 67    0.93 (0.88–.97) 73 99    0.96 (0.93–1) 97 66    0.96 (0.93–1)
Yanaranop et al. [31]   84 53 41 89 0.81 (0.74–0.87) 66 86 65 87 0.82 (0.76–.89)      
Wilailak et al. [32]       0.87 (0.80–0.93)      0.89 (0.84–0.95)      0.89 (0.84–0.95)
Wang et al. [36] X 79 (74–84) 82 (77–87)    0.87 (0.84–0.90) 76 (72–80) 94 (90–96)    0.89 (0.86–0.92)      
Zhen et al. [37] X 74 (72–76) 83 (81–84)    0.85 74 (72–76) 90 (89–91)    0.89      
Abdel-Azeez et al. [45]   73 (57–86) 79 (58–93)    0.90 (0.82–0.97) 83 (68–93) 88 (68–97)    0.95 (0.90–1) 90 79    
Holcomb et al. [46]   85 (69–95) 59 (52–66) 27 96   65 (46–80) 92 (87–95) 58 94   91 55 26 97  
Moore et al. [48]    61    0.84 (0.77–0.90)   78    0.91 (0.86–0.95)   81    0.91 (0.87–0.96)
Goff et al. [52]   79 (67–88) 76 (68–83) 63 87   58 (45–70) 94 (88–97) 83 81       
Meys et al. [55] X                
Van Gorp et al. [56]   80 (72–85) 82 (76–86)     75 (67–81) 83 (78–88)         
Al Musalhi et al. [57]   79 62 38 91 0.81 71 90 68 91 0.82      
Moore et al. [62]             89 (85–93) 75 (70–79) 60 94  
Li et al. [64] X 77 (58–89) 84 (76–90)    0.88 (0.85–0.91) 79 (74–84) 93 (87–96)    0.82 (0.78–0.85)      
Wei et al. [66]   85 92 91 89   75 98 96 85       
Sandri et al. [67]   91 71    0.90 (0.86–0.93) 83 91    0.92 (0.89–.95)      
  1. CA125 carbohydrate antigen 125, HE4 human epididymis protein 4, Se sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, AUC area under the curve