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Table 1 The associations of each SIRT member’s expression with RFS and OS

From: Development and validation of SIRT3-related nomogram predictive of overall survival in patients with serous ovarian cancer

Variables Number of patients RFS OS
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
HR (95%CI) P value HR (95%CI) P value HR (95%CI) P value HR (95%CI) P value
Age 462 1.003 (0.991–1.014) 0.661 / / 1.024 (1.013–1.036) < 0.001 1.023 (1.011–1.034) < 0.001
Stage    0.015   0.016   0.001   0.005
 Early 33 1   1   1   1  
 Late 429 2.003 (1.144–3.506)   1.986 (1.134–3.477)   3.478 (1.639–7.381)   2.995 (1.392–6.446)  
Grade    0.254   /   0.048   0.196
 Low 57 1   /   1   1  
 High 405 1.227 (0.863–1.745)   /   1.438 (1.003–2.063)   1.280 (0.881–1859)  
Debulking    0.886   /   0.030   0.540
 Optimal 344 1   /   1   1  
 Suboptimal 118 0.979 (0.734–1.306)   /   1.353 (1.030–1.776)   0.915 (0.689–1.216)  
SIRT1 462 0.824 (0.662–1.026) 0.084 / / 0.907 (0.727–1.131) 0.386 / /
SIRT2 462 1.061 (0.814–1.384) 0.660 / / 1.187 (0.925–1.522) 0.178 / /
SIRT3 462 1.043 (0.690–1.576) 0.841 / / 0.661 (0.438–0.996) 0.048 0.588 (0.389–0.889) 0.012
SIRT4 462 0.629 (0.385–1.028) 0.064 / / 0.627 (0.374–1.052) 0.077 / /
SIRT5 462 1.013 (0.856–1.199) 0.879 / / 0.815 (0.688–0.967) 0.019 0.882 (0.742–1.049) 0.157
SIRT6 462 1.102 (0.697–1.744) 0.677 / / 0.794 (0.505–1.249) 0.318 / /
SIRT7 462 0.786 (0.620–0.997) 0.047 0.791 (0.624–1.003) 0.053 0.760 (0.595–0.969) 0.027 0.786 (0.613–1.008) 0.058