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Table 2 Pooled hazard ratios (HRs) for OS according to subgroup analyses

From: Prognostic value of lymphocyte-to-monocyte ratio in ovarian cancer: a meta-analysis

Subgroup No. of studies No. of patients HR (95% CI) P value Heterogeneity
I2(%) Ph
Overall 8 5368 0.63 (0.50–0.80) < 0.001 65.9 0.005
Ethnicity
 Asian 2 422 0.46 (0.25–0.87) 0.016 73.3 0.023
 Caucasian 5 4946 0.80 (0.71–0.89) < 0.001 8.2 0.360
Disease stage
 Early 2 536 0.61 (0.20–1.82) 0.377 0 0.705
 Mixed 6 4832 0.63 (0.49–0.80) < 0.001 75.3 0.001
Treatment
 Surgery 4 4878 0.81 (0.74–0.89) < 0.001 0 0.883
 Mixed 4 482 0.45 (0.27–0.73) 0.001 62.3 0.047
Cut-off for LMR
  ≥ 3 5 4930 0.56 (0.35–0.88) 0.011 76.6 0.002
  <  3 3 438 0.65 (0.41–1.04) 0.075 41.7 0.180
Analysis method
 Univariate 2 185 0.46 (0.27–0.79) 0.005 0 0.488
 Multivariate 6 5183 0.67 (0.53–0.86) 0.001 65.9 0.005