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Table 1 Experimental studies that investigated the role of quercetin in ovarian cancer

From: Quercetin: a natural compound for ovarian cancer treatment

Form of quercetin Doses Type of cervical cancer Model Findings Ref
Quercerin 80 mg/kg twice a week In vivo Induced apoptosis, induced ER stress, activated p-STAT3/ Bcl2 axis, induced protective authophagy, [78]
34′7TMQ Epithelial and fibroblast ovarian cancer cell lines In vitro Inhibited cell migration and invasion, inhibited expression of uPA and MMP-2 [90]
Quercetin A dose range Metastatic ovarian cancer cell line In vitro Decreased viability, induced apoptosis, decreased Bcl-2 and Bcl-xL, increased caspase-3, caspase-p, Bid, Bad, Bax, cytochrome c [79]
Quercetin 100 μM Multi-drug resistant ovarian cancer cell line In vitro Increased ER stress, prolonged DNA repair, increased expression of p53, p21 and Bax, decreased expression of Bcl-2, induced radio-sensitization, [81]
Quercetin Human ovarian cancer xenograft model In vivo increased radiation-induced cell death, increased p53, increased ER stress  
Quercetin A dose range Cisplatin sensitive and resistant cell lines In vitro Enhanced cisplatin cytotoxicity, increased ER stress, suppressed STAT-3 phosphorylation, decreased expression of Bcl-2, [82]
  40 mg/kg once a week Human ovarian cancer xenograft model In vivo Suppressed STAY-3 phosphorylation, decreased Bcl-2 expression, induced apoptosis  
Quercetin A dose range Epithelial ovarian cancer cell line and its CIS-resistant cell line In vitro Decreased expression of cyclin D1 [85]
Quercetin A dose range Epithelial ovarian cancer cell line In vitro Inhibited proliferation, induced apoptosis, decreased survivin, induced cell cycle arrest [86]
Nano-formulation of quercetin A dose range Ovarian endometrioid adenocarcinoma In vitro Inhibited growth, induced apoptosis, activated caspase-3 and caspase-9, decreased expression of MCL-1 and Bcl-2, increased expression of Bax [80]
  A dose range Human ovarian cancer xenograft model In vivo Inhibited growth, induced apoptosis, inhibited angiogenesis  
Quercetin A dose range Epithelial and drug resistant ovarian cancer cell lines In vitro Decreased ROS, increased anti-oxidant enzymes, inhibited apoptosis [91]
   Human ovarian cancer xenograft model In vivo Increased anti-oxidant enzymes expression, reduced ROS, decreased anti-neoplastic drug’s efficacy  
Lipo-Que CIS-resistant and CIS-sensitive ovarian cancer cell lines In vitro Inhibited proliferation, induced apoptosis, induced cell cycle arrest [83]
   Human ovarian cancer xenograft model In vivo Inhibited tumor growth, inhibited proliferation, induced apoptosis  
Quercetin 2 mg / kg Human ovarian cancer xenograft model In vivo Increased TRAIL sensitization, inhibited tumor growth, increased caspase-3, induced apoptosis [88]
Quercetin 10 microM Ovarian serous adenocarcinoma In vitro Increased TGF beta 1 activity [89]
Quercetin A dose range Metastatic ovarian serous adenocarcinoma In vitro Inhibited PI kinase, decreased IP3 levels [87]