Skip to main content

Table 3 Bottlenecks proteins with significant centrality values, based on betweeness

From: Proteome profiling of low grade serous ovarian cancer

Num Bottleneck genes Protein names Betweeness
1 ACTB actin beta(ACTB) 0.873
2 APOA1 apolipoprotein A1(APOA1) 0.222
3 PRDX2 peroxiredoxin 2(PRDX2) 0.202
4 TAGLN transgelin(TAGLN) 0.114
5 HP haptoglobin(HP) 0.048
6 KRT1 keratin 1(KRT1) 0.036
7 FN1 fibronectin 1(FN1) 0.026
8 APP amyloid beta precursor protein(APP) 0.026
9 ESR1 estrogen receptor 1(ESR1) 0.026
10 UCHL5 ubiquitin C-terminal hydrolase L5(UCHL5) 0.026
11 FBLN1 fibulin 1(FBLN1) 0.017
12 TTR transthyretin(TTR) 0.016
13 KRT9 keratin 9(KRT9) 0.016
14 VCP valosin containing protein(VCP) 0.016
15 BAZ1B bromodomain adjacent to zinc finger domain 1B(BAZ1B) 0.016
16 APOE apolipoprotein E(APOE) 0.009
17 CFL1 cofilin 1(CFL1) 0.008
18 NCF1 neutrophil cytosolic factor 1(NCF1) 0.008
19 TINF2 TERF1 interacting nuclear factor 2(TINF2) 0.008
20 ACD adrenocortical dysplasia homolog(ACD) 0.008
21 POT1 protection of telomeres 1(POT1) 0.008
22 PRKCD protein kinase C delta(PRKCD) 0.008
23 ISG15 ISG15 ubiquitin-like modifier(ISG15) 0.008
24 ENO1 enolase 1(ENO1) 0.008
25 TPM2 tropomyosin 2 (beta)(TPM2) 0.008
26 LMOD1 leiomodin 1(LMOD1) 0.008
27 JUN Jun proto-oncogene, AP-1 transcription factor subunit(JUN) 0.007
28 GPX4 glutathione peroxidase 4(GPX4) 0.006
29 HINT1 histidine triad nucleotide binding protein 1(HINT1) 0.006
30 VCAM1 vascular cell adhesion molecule 1(VCAM1) 0.005
31 MAP1LC3A microtubule associated protein 1 light chain 3 alpha(MAP1LC3A) 0.005
32 MAP1LC3B microtubule associated protein 1 light chain 3 beta(MAP1LC3B) 0.005
33 GABARAPL2 GABA type A receptor associated protein like 2(GABARAPL2) 0.005
34 GABARAPL1 GABA type A receptor associated protein like 1(GABARAPL1) 0.005
35 GABARAP GABA type A receptor-associated protein(GABARAP) 0.005
36 PPARG peroxisome proliferator activated receptor gamma(PPARG) 0.005
37 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta(YWHAZ) 0.005
38 RAD52 RAD52 homolog, DNA repair protein(RAD52) 0.005
39 CDC37 cell division cycle 37(CDC37) 0.005
40 NFKB1 nuclear factor kappa B subunit 1(NFKB1) 0.005
41 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1(OTUB1) 0.005
42 UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked(UTY) 0.005
43 ITGA4 integrin subunit alpha 4(ITGA4) 0.005
44 COPS5 COP9 signalosome subunit 5(COPS5) 0.005
45 HSPA5 heat shock protein family A (Hsp70) member 5(HSPA5) 0.005
46 CUL2 cullin 2(CUL2) 0.005
47 CDK2 cyclin dependent kinase 2(CDK2) 0.005
48 CUL1 cullin 1(CUL1) 0.005
49 CAND1 cullin associated and neddylation dissociated 1(CAND1) 0.005
50 ANXA2 annexin A2(ANXA2) 0.005
51 BCAR1 BCAR1, Cas family scaffolding protein(BCAR1) 0.005
52 PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase(PCMT1) 0.004
53 SMAD3 SMAD family member 3(SMAD3) 0.004
54 GRB2 growth factor receptor bound protein 2(GRB2) 0.004
55 ITGAM integrin subunit alpha M(ITGAM) 0.004
56 ITGB2 integrin subunit beta 2(ITGB2) 0.004