Table 3 Bottlenecks proteins with significant centrality values, based on betweeness
Num | Bottleneck genes | Protein names | Betweeness |
|---|---|---|---|
1 | ACTB | actin beta(ACTB) | 0.873 |
2 | APOA1 | apolipoprotein A1(APOA1) | 0.222 |
3 | PRDX2 | peroxiredoxin 2(PRDX2) | 0.202 |
4 | TAGLN | transgelin(TAGLN) | 0.114 |
5 | HP | haptoglobin(HP) | 0.048 |
6 | KRT1 | keratin 1(KRT1) | 0.036 |
7 | FN1 | fibronectin 1(FN1) | 0.026 |
8 | APP | amyloid beta precursor protein(APP) | 0.026 |
9 | ESR1 | estrogen receptor 1(ESR1) | 0.026 |
10 | UCHL5 | ubiquitin C-terminal hydrolase L5(UCHL5) | 0.026 |
11 | FBLN1 | fibulin 1(FBLN1) | 0.017 |
12 | TTR | transthyretin(TTR) | 0.016 |
13 | KRT9 | keratin 9(KRT9) | 0.016 |
14 | VCP | valosin containing protein(VCP) | 0.016 |
15 | BAZ1B | bromodomain adjacent to zinc finger domain 1B(BAZ1B) | 0.016 |
16 | APOE | apolipoprotein E(APOE) | 0.009 |
17 | CFL1 | cofilin 1(CFL1) | 0.008 |
18 | NCF1 | neutrophil cytosolic factor 1(NCF1) | 0.008 |
19 | TINF2 | TERF1 interacting nuclear factor 2(TINF2) | 0.008 |
20 | ACD | adrenocortical dysplasia homolog(ACD) | 0.008 |
21 | POT1 | protection of telomeres 1(POT1) | 0.008 |
22 | PRKCD | protein kinase C delta(PRKCD) | 0.008 |
23 | ISG15 | ISG15 ubiquitin-like modifier(ISG15) | 0.008 |
24 | ENO1 | enolase 1(ENO1) | 0.008 |
25 | TPM2 | tropomyosin 2 (beta)(TPM2) | 0.008 |
26 | LMOD1 | leiomodin 1(LMOD1) | 0.008 |
27 | JUN | Jun proto-oncogene, AP-1 transcription factor subunit(JUN) | 0.007 |
28 | GPX4 | glutathione peroxidase 4(GPX4) | 0.006 |
29 | HINT1 | histidine triad nucleotide binding protein 1(HINT1) | 0.006 |
30 | VCAM1 | vascular cell adhesion molecule 1(VCAM1) | 0.005 |
31 | MAP1LC3A | microtubule associated protein 1 light chain 3 alpha(MAP1LC3A) | 0.005 |
32 | MAP1LC3B | microtubule associated protein 1 light chain 3 beta(MAP1LC3B) | 0.005 |
33 | GABARAPL2 | GABA type A receptor associated protein like 2(GABARAPL2) | 0.005 |
34 | GABARAPL1 | GABA type A receptor associated protein like 1(GABARAPL1) | 0.005 |
35 | GABARAP | GABA type A receptor-associated protein(GABARAP) | 0.005 |
36 | PPARG | peroxisome proliferator activated receptor gamma(PPARG) | 0.005 |
37 | YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta(YWHAZ) | 0.005 |
38 | RAD52 | RAD52 homolog, DNA repair protein(RAD52) | 0.005 |
39 | CDC37 | cell division cycle 37(CDC37) | 0.005 |
40 | NFKB1 | nuclear factor kappa B subunit 1(NFKB1) | 0.005 |
41 | OTUB1 | OTU deubiquitinase, ubiquitin aldehyde binding 1(OTUB1) | 0.005 |
42 | UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked(UTY) | 0.005 |
43 | ITGA4 | integrin subunit alpha 4(ITGA4) | 0.005 |
44 | COPS5 | COP9 signalosome subunit 5(COPS5) | 0.005 |
45 | HSPA5 | heat shock protein family A (Hsp70) member 5(HSPA5) | 0.005 |
46 | CUL2 | cullin 2(CUL2) | 0.005 |
47 | CDK2 | cyclin dependent kinase 2(CDK2) | 0.005 |
48 | CUL1 | cullin 1(CUL1) | 0.005 |
49 | CAND1 | cullin associated and neddylation dissociated 1(CAND1) | 0.005 |
50 | ANXA2 | annexin A2(ANXA2) | 0.005 |
51 | BCAR1 | BCAR1, Cas family scaffolding protein(BCAR1) | 0.005 |
52 | PCMT1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase(PCMT1) | 0.004 |
53 | SMAD3 | SMAD family member 3(SMAD3) | 0.004 |
54 | GRB2 | growth factor receptor bound protein 2(GRB2) | 0.004 |
55 | ITGAM | integrin subunit alpha M(ITGAM) | 0.004 |
56 | ITGB2 | integrin subunit beta 2(ITGB2) | 0.004 |