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Table 2 Differential diagnosis and pathological features of LCNEC

From: Pathological features, clinical presentations and prognostic factors of ovarian large cell neuroendocrine carcinoma: a case report and review of published literature

Differential diagnosisPathological features
LCNECSolid nests or trabecular patterns, large tumor cell with high mitotic rate [3, 6, 20].
Positive reactivity for CgA, Syn, CK and CD56 [5, 6, 8, 11, 40, 44].
Primary or metastatic carcinoid tumorUniform cell with rare mitotic figure and inexistent necrosis [17].
SCC pulmonary typeSmaller cell with obvious necrosis and less-intense immunohistochemical reactivity for CK and CgA. [30].
SCC hypercalcemic typeFollicle-like spaces,large cells with pale intracytoplasmic hyaline globules [10, 45, 46] and clinical manifestations of hypercalcemia [30].
Metastatic neuroendocrine carcinomaBilateral ovarian involvement, vascular invasion and inmiscibility with epithelial layer of the ovary [23, 30].
Non-neuroendocrine tumors with neuroendocrine differentiationIdentifying non-neuroendocrine components of teratoma, sex-cord stromal tumor and Sertoli-Leydig cell tumor.[3, 10, 15, 17, 25].