Fig. 1
From: Pioglitazone suppresses excessive follicular development in murine preantral follicles
Effect of androgen (DHT) and insulin-sensitizer (pioglitazone) on follicle survival rates. Survival rates were determined under low follicle-stimulating hormone (FSH; 33 mIU/mL) at day 13 of culture. 1) Control (CTRL) group, base media plus DHT vehicle (100% ethanol) and pioglitazone vehicle (dimethyl sulfoxide; DMSO); 2) DHT group, CTRL media plus 500 ng/mL DHT and DMSO; 3) pioglitazone group, CTRL media plus 5 ng/mL pioglitazone and ethanol; and 4) DHT + pioglitazone group, CTRL media plus 500 ng/mL DHT and 5 ng/mL pioglitazone. Data are expressed as mean ± standard error. There was no significant difference in follicle survival rates among these groups (P = 0.833), by one-way ANOVA