Fig. 2
From: Pioglitazone suppresses excessive follicular development in murine preantral follicles
Effect of androgen (DHT) and insulin-sensitizer (pioglitazone) on average follicle diameters. Follicle growth was monitored at the indicated time points. 1) CTRL group, base media plus DHT vehicle (100% ethanol) and pioglitazone vehicle (dimethyl sulfoxide; DMSO); 2) DHT group, CTRL media plus 500 ng/mL DHT and DMSO; 3) pioglitazone group, CTRL media plus 5 ng/mL pioglitazone and ethanol; and 4) DHT + pioglitazone group, CTRL media plus 500 ng/mL DHT and 5 ng/mL pioglitazone. Data are expressed as mean ± standard error. Statistically significant differences among culture conditions are indicated by different letters