Skip to main content
Fig. 5 | Journal of Ovarian Research

Fig. 5

From: Pioglitazone suppresses excessive follicular development in murine preantral follicles

Fig. 5

Effects of androgen (DHT) and insulin-sensitizer (pioglitazone) on gene expression of hormone receptors, Cyp19a1, Pten, and Vegf. Isolated follicles were cultured for 13 days and then analyzed for gene expression of a Fshr, b Ar, c Cyp19a1, d Pten, and e Vegf. 1) CTRL group, base media plus DHT vehicle (100% ethanol) and pioglitazone vehicle (dimethyl sulfoxide; DMSO); 2) DHT group, CTRL media plus 500 ng/mL DHT and DMSO; 3) pioglitazone group, CTRL media plus 5 ng/mL pioglitazone and ethanol; and 4) DHT + pioglitazone group, CTRL media plus 500 ng/mL DHT and 5 ng/mL pioglitazone. Data are expressed as mean ± standard error, and have been log2 transformed. All groups were compared with the control group. *P < 0.05, by one-way ANOVA and Student-Newman-Keuls post-hoc analysis

Back to article page