Table 1 Selected circular RNAs in different cancers

GC

CiRS-7

Up

miR-7

Increase the overall survival

In vitro

Tissue,

cell line

Circ_104,916

Down

Unknown

Promote TNM and lymph node metastasis

In vitro

Tissue,

cell line

[36]

Circ_0000181

Down

Unknown

Lymphatic metastasis and distal metastasis

In vitro

Tissues, plasma

[37]

BLC

CircHIPK3

Down

miR-558

Promote Vascular invasion and lymph node metastasis

In vitro, In vivo

Tissue,

Cell line

mice

[38]

CircTCF25

Up

miR-103a

miR-107

CDK6

Promote cell proliferation,

Migration

In vitro

Tissue, Cell line

[39]

CircRNA BCRC4

Down

miR-101

Association with cell apoptosis

In vitro

Tissue, Cell line

[40]

ESCC

Circ-ITCH

Down

miR-7 miR-17 miR-214

Inhibit the Wnt/β-catenin pathway

In vitro, In vivo

Tissue,

Cell line

[41]

hsa_circ_0067934

Up

Unknown

Promote the proliferation and migration

In vitro

Tissue, cell line

[42]

circ-DLG 1

Up

miR-515

miR-942

miR-589

miR-136

Promote the esophageal cell proliferation ability

In vitro

Tissue, cell line,

Plasma

[43]

BC

hsa_circ_0001982

Up

miR-143

Promote the proliferation and invasion and suppress apoptosis

In vitro

Cell line,

Tissue

[44]

CircMYO9B

Up

miR-4316

Promote the BC cell proliferation, migration and invasion, upregulation of FOXP4

In vitro, In vivo

Tissue,

Cell line

[45]

hsa_circ_0007534

Up

miR-593

Promote the BC cell proliferation, colony formation, and invasion, upregulation of Mucin 19 (MUC19)

In vitro

Tissue,

Cell line

[46]

CRC

CircITGA7

Down

miR-370-3p

Promote the proliferation and metastasis in CRC cells via Ras pathway

In vitro, In vivo

Tissues,

cell line

[47]

hsa_circ_0000523

Down

miR-31

Promote the proliferation and suppressed apoptosis of CRC cells via indirectly regulating Wnt/β-catenin signaling pathway

In vitro, In vivo

Tissues,

cell line

[48]

Circ-001569

Up

miR-145

Promote the proliferation, cell growth and invasion of CRC

In vitro

Tissues,

cell line

HCC

CSMARCA5

Down

miR-17-3p

miR-181b-5p

Promote the growth and metastasis of HCC

In vitro, In vivo

Tissues,

cell line

[49]

CircMTO1

Down

miR-9

Promote the HCC progression and cell growth via miR9-P21

In vitro, In vivo

Tissues,

cell line

Circ_100,338

Up

miR-141-3p

Promote the lung metastasis, vascular invasion, and TNM

In vitro, In vivo

Tissues,

cell line

[50]

OSCC

CircRNA_100290

Up

miR-29b

Suppress G1/S arrest, induce cell proliferation and upregulate the expression of CDK6

In vitro, In vivo

Tissues,

cell line

[51]

hsa_circ_0055538

Down

p53/Bax/Apaf1/

caspase-3/

p21/Bcl2

Development of OSCC via the p53/Bcl-2/caspase signaling pathway.

In vitro, In vivo

Tissues,

Cell line

[52]

CircDOCK1

Up

miR-196a-5p

Inhibit the cell apoptosis via miR-196a-5p/BIRC3 pathway

In vitro, In vivo

Tissues,

Cell line

[53]

PCa

Circ-SMARCA5

Up

Unknown

Promote the cell cycle and inhibited cell apoptosis

In vitro

Cell line

[54]

Circ-102,004

Up

ERK/JNK/ Hedgehog

Promote the cell proliferation and decrease cell apoptosis in PCa

In vitro, In vivo

Tissues,

Cell line

[55]

CircMYLK

Up

MiR-29a

Promote the PCa cell proliferation, invasion, and migration

In vitro

Tissue,

Cell line

[56]

LC

Circ_100876

Up

Unknown

Promote the lymph node metastasis/TNM and overall survival

In vitro

Tissues

[57]

CircFARSA

Up

miR-330-5p

miR-326

FASN

Promote the cell migration and invasion

In vitro,

In silico

Tissue,

Plasma

[58]

CircRNF13

Down

miR-93-5p

Inhibit the cell invasion and metastasis

In vitro

Tissues,

Cell line

[59]

hsa_circ_0001564

Up

miR-29c-3p

Promote the proliferation activity, repressed cell cycle arrest in G0/G1 phase, and suppressed apoptosis

In vitro

Tissues,

Cell line

[60]

circ-0016347

Up

miR-214

Promote the proliferation, invasion and metastasis

In vitro, In vivo

Tissues, Cell line

[61]

circUBAP2

Up

miR-143

Promote the osteosarcoma growth and inhibit the apoptosis, and promote the osteosarcoma progression

In vitro, In vivo

Tissues, Cell line

[62]