From: Circular RNAs in cancer: new insights into functions and implications in ovarian cancer
Circular RNA | Regulation of the expression in cancer | Genetic target (s) | Effect (s) | Model used | Type of cell line/ Number of sample (Human) | Reference |
---|---|---|---|---|---|---|
circ_0031356, 0093477, 0110166, 0126526, 0130590 and 0135175) | Down regulated | – | – | In silico | – | [79] |
Circ-ITCH | Down regulated | miR-145 | Up regulation of RASA1, inhibit the tumorigenesis | In vitro, In vivo and Human | SK-OV-3 and Caov-3 cell lines, BALB/c nude mice/20 | [80] |
circ_0004712, circ_0002198, circ_0008951, circ_0017248 and circ_0003570 | Up regulated Up regulated Up regulated Up regulated Down regulated | Â | Upregulation of SCN3B, ENTPD1, BACH2, C3 and G0S2, down regulation of CKS2 and PGRMC1 | Human | 41 | [81] |
VPS13C-has-circ-001567, RAD50-has-circ-00718, and SPECC1-has-circ-000013 | Up regulated | Â | Increase the proliferation, migration, invasion E-cadherin and N-cadherin | In vitro, In vivo, Human | SK-OV-3, OV-1063 cell lines/20 | [82] |
circEPST1 | Up regulated | miR-942 | Upregulation of EPST1 | In vivo, In vitro | OV119 and A2780 cell line/50 | [83] |
Circ-CSSP1 | Up regulated | miR-1236-3p | Upregulation of ZEB1, and promote the EMT transition | In vitro, In vivo | SK-OV-3, A2780 and CAOV3 cell lines | [84] |
Circ-HIPK3 | Up regulated | – | Promote the lymph node invasion and advanced stage | In vitro, Human | ,A2780, HO8910, SK-OV-3 and CAOV3 cell lines/69 | [85] |
Circ-HIPK3, circRHOBTB3, circPCMTD1, circSETD3, circATRNL1, circAC139769.1 | Down regulated Down regulated Down regulated Down regulated Down regulated Up regulated | Â | Promote the apoptosis and inhibit the proliferation and invasion | In vitro, Human | A2780,SK-OV-3,HO8910, OVCAR8,COC1and IOSE80 cell lines /21 | [86] |
circHIPK3, circRNA2058, circRNA3336, circRNA2606, circRNA1656, circRNA1312 and circRNA7474 | Down regulated Down regulated Down regulated Down regulated Down regulated Up regulated Up regulated | – | – | In vitro, Human | SK-OV-3, HO 8910, OVCAR-3, and A2780 cell lines/60 | [87] |
hsa_circ_0051240 | Up regulated | miR-637 | Upregulation of KLK4 | In vitro, In vivo, Human | CAOV-3, SKOV-3, OVCAR-3 and H8910/ 33 | [88] |
Circ-ITCH | Down regulated | miR-10a | Enhance the apoptosis | In vitro | SKOV3, A-2780, OVCAR-3 and HO-8910 | [89] |
Circ-LARP4 | Down regulated | Â | Lower expression is associated with advanced grade | Human | 78 | [90] |
circBNC2, circEXOC6B, circFAM13B, circN4BP2L2, circRHOBTB3 and circCELSR1 | Down regulated, Down regulated, Down regulated, Down regulated, Down regulated, Up regulated | Â | Â | Human | 54 | [91] |