Skip to main content

Table 2 Studies concerning Circular RNAs and Ovarian Cancer

From: Circular RNAs in cancer: new insights into functions and implications in ovarian cancer

Circular RNA

Regulation of the expression in cancer

Genetic target (s)

Effect (s)

Model used

Type of cell line/ Number of sample (Human)

Reference

circ_0031356, 0093477, 0110166, 0126526, 0130590 and 0135175)

Down regulated

–

–

In silico

–

[79]

Circ-ITCH

Down regulated

miR-145

Up regulation of RASA1, inhibit the tumorigenesis

In vitro, In vivo and Human

SK-OV-3 and Caov-3 cell lines, BALB/c nude mice/20

[80]

circ_0004712, circ_0002198, circ_0008951, circ_0017248

and circ_0003570

Up regulated

Up regulated

Up regulated

Up regulated

Down regulated

 

Upregulation of SCN3B, ENTPD1, BACH2, C3 and G0S2, down regulation of CKS2 and PGRMC1

Human

41

[81]

VPS13C-has-circ-001567, RAD50-has-circ-00718,

and SPECC1-has-circ-000013

Up regulated

 

Increase the proliferation, migration, invasion E-cadherin and N-cadherin

In vitro, In vivo, Human

SK-OV-3, OV-1063 cell lines/20

[82]

circEPST1

Up regulated

miR-942

Upregulation of EPST1

In vivo, In vitro

OV119 and A2780 cell line/50

[83]

Circ-CSSP1

Up regulated

miR-1236-3p

Upregulation of ZEB1, and promote the EMT transition

In vitro, In vivo

SK-OV-3, A2780 and CAOV3 cell lines

[84]

Circ-HIPK3

Up regulated

–

Promote the lymph node invasion and advanced stage

In vitro, Human

,A2780, HO8910, SK-OV-3 and CAOV3 cell lines/69

[85]

Circ-HIPK3, circRHOBTB3, circPCMTD1, circSETD3, circATRNL1, circAC139769.1

Down regulated Down regulated

Down regulated

Down regulated

Down regulated

Up regulated

 

Promote the apoptosis and inhibit the proliferation and invasion

In vitro,

Human

A2780,SK-OV-3,HO8910, OVCAR8,COC1and IOSE80 cell lines /21

[86]

circHIPK3, circRNA2058, circRNA3336, circRNA2606, circRNA1656, circRNA1312 and circRNA7474

Down regulated

Down regulated

Down regulated

Down regulated

Down regulated

Up regulated

Up regulated

–

–

In vitro,

Human

SK-OV-3, HO 8910, OVCAR-3, and A2780 cell lines/60

[87]

hsa_circ_0051240

Up regulated

miR-637

Upregulation of KLK4

In vitro,

In vivo, Human

CAOV-3, SKOV-3, OVCAR-3 and H8910/ 33

[88]

Circ-ITCH

Down regulated

miR-10a

Enhance the apoptosis

In vitro

SKOV3, A-2780,

OVCAR-3 and HO-8910

[89]

Circ-LARP4

Down regulated

 

Lower expression is associated with advanced grade

Human

78

[90]

circBNC2, circEXOC6B, circFAM13B, circN4BP2L2, circRHOBTB3 and circCELSR1

Down regulated,

Down regulated,

Down regulated,

Down regulated,

Down regulated,

Up regulated

  

Human

54

[91]

  1. BACH2 BTB Domain And CNC Homolog 2, CKS2 Cyclin-dependent kinase subunit 2, EMT epithelial–mesenchymal transition, EPST1 epithelial-stromal interaction 1, G0S2 G0/G1 switch gene 2, KLK4:Kallikrein-related peptidase 4, RASA1 RAS P21 Protein Activator 1, SCN3B Sodium channel subunit beta-3, PGRMC1 Progesterone receptor membrane component 1, ENTPD1 Ectonucleoside Triphosphate Diphosphohydrolase 1, ZEB1 Zinc finger E-box-binding homeobox 1