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Table 2 Immunohistochemical staining on the different histological components

From: Canine ovarian gonadoblastoma with dysgerminoma overgrowth: a case study and literature review

Marker Immunohistochemical reactivity b
Gonadoblastoma Dysgerminoma Sex cord-stromal tumour
Germ cells Sex cord-stromal cells
c-KIT (CD117) ++ ++
α-inhibin +++ −/+++
Pan-cytokeratin +++
Vimentin + ++ + ++
Oestrogen receptor
EMA
Ki-67 PI a < 1% 23%
  1. aKi-67 PI (proliferative index): percentage of positive nuclei, determined by counting 1.000 nuclei per 10 high-power fields
  2. bScoring: -, negative; +, weak; ++, moderate; +++, strong