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Table 1 Clinicpathological parameters associated with AFR in advanced EOC patients

From: Preoperative albumin-to-fibrinogen ratio predicts chemotherapy resistance and prognosis in patients with advanced epithelial ovarian cancer

  AFR  
Parameters Low (≤7.78) High (> 7.78) p value
Number 151 162
Age (years) 65.8 ± 8.7 63.1 ± 7.8 0.004*
BMI (kg/m2) 23.1 ± 2.3 23.4 ± 2.1 0.229
Current smokers (n, %) 18 (11.9) 24 (14.8) 0.453
Alcohol (n, %) 14 (9.3) 19 (11.7) 0.479
Comorbidities (n, %)
 Diabetes 22 (14.6) 17 (10.5) 0.275
 Hypertension 27 (17.9) 22 (13.6) 0.295
 Hyperlipemia 15 (9.9) 12 (7.4) 0.426
Histological grade (n, %) 0.042*
 G1 76 (50.3) 100 (61.7)
 G2/3 75 (49.7) 62 (38.3)
Histological type (n, %) 0.444
 Serous 106 (70.2) 120 (74.1)
 Non-serous 45 (29.8) 42 (25.9)
FIGO stage (n, %) 0.032*
 III 113 (74.8) 137 (84.6)
 IV 38 (25.2) 25 (15.4)
ECOG PS (n, %) 0.016*
 0 101 (66.9) 128 (79.0)
  ≥ 1 50 (33.1) 34 (21.0)
Chemotherapy resistance (n, %) 54 (35.8) 40 (24.7) 0.033*
Residual tumor (cm) 0.005*
  ≤ 1 100 (66.2) 130 (80.2)
  > 1 51 (33.8) 32 (19.8)
  1. EOC, Epithelial ovarian cancer; BMI, Body mass index; FIGO, International Federation of Gynecology and Obstetrics; AFR, Albumin-to-fibrinogen ratio; ECOG PS, Eastern cooperative oncology group performance status. P-values were calculated by Student’s t test, Mann–Whitney U test or Chi-squared test. * P < 0.05.