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Table 3 Risk factors for PFS by univariate and multiple Cox regression analysis

From: Preoperative albumin-to-fibrinogen ratio predicts chemotherapy resistance and prognosis in patients with advanced epithelial ovarian cancer

  Univariate   Multivariate  
Parameters HR(95% CI) p value HR(95% CI) p value
Age (high vs low) 1.50 (1.11–2.08) 0.016* 1.17 (0.85–1.62) 0.301
BMI (high vs low) 0.82 (0.61–1.15) 0.251   
Current smokers (yes vs no) 1.28 (0.97–1.70) 0.112   
Alcohol (yes vs no) 1.16 (0.89–1.53) 0.247   
Diabetes (yes vs no) 1.03 (0.75–1.41) 0.822   
Hypertension (yes vs no) 1.06 (0.73–1.49) 0.794   
Hyperlipemia (yes vs no) 0.85 (0.42–1.65) 0.654   
Histological grade (G2/3 vs G1) 1.76 (1.19–2.63) 0.012* 1.63 (0.92–2.77) 0.093
Histological type (serous vs non-serous) 1.21 (0.89–1.59) 0.179   
FIGO stage (IV vs III) 1.72 (1.09–2.73) 0.024* 1.44 (0.79–2.69)0.254  
ECOG PS (≥1 vs 0) 0.86 (0.71–1.07) 0.852   
Chemotherapy resistance (yes vs no) 2.07 (1.35–3.17) 0.011* 1.84 (1.12–2.88) 0.032*
Residual tumor (> 1 cm vs ≤1 cm) 2.01 (0.94–4.31) 0.071 1.61 (0.91–2.85) 0.121
Hemoglobin (high vs low) 1.84 (0.69–4.78) 0.211   
Platelet (high vs low) 1.55 (0.38–5.78) 0.529   
WBC (high vs low) 1.86 (0.86–3.89) 0.127   
Albumin (high vs low) 0.92 (0.57–1.42) 0.721   
Total protein (high vs low) 0.81 (0.44–1.48) 0.472   
Total cholesterol (high vs low) 0.75 (0.47–1.24) 0.261   
Triglyceride (high vs low) 1.26 (0.70–2.22) 0.425   
CA125 (high vs low) 1.72 (1.22–2.44) 0.011* 1.42 (1.02–2.05) 0.042*
CRP (high vs low) 1.36 (0.69–2.64) 0.373   
AFR (≤7.78 vs > 7.78) 1.56 (1.21–2.05) 0.007* 1.38 (1.04–1.82) 0.019*
  1. EOC, Epithelial ovarian cancer; PFS, Progression-free survival; BMI, Body mass index; FIGO, International Federation of Gynecology and Obstetrics; AFR, Albumin-to-fibrinogen ratio; ECOG PS, Eastern cooperative oncology group performance status; WBC, White blood cell; CRP, C-reactive protein; HR, Hazard ratio; CI, Confidence interval. * P < 0.05.