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Table 4 Risk factors for OS by univariate and multiple Cox analysis

From: Preoperative albumin-to-fibrinogen ratio predicts chemotherapy resistance and prognosis in patients with advanced epithelial ovarian cancer

 

Univariate

Multivariate

Parameters

HR(95% CI)

p value

HR(95% CI)

p value

Age (high vs low)

1.23 (0.84–1.81)

0.304

  

BMI (high vs low)

0.53 (0.24–1.15)

0.112

  

Current smokers (yes vs no)

1.09 (0.76–1.57)

0.647

  

Alcohol (yes vs no)

1.17 (0.82–1.67)

0.384

  

Diabetes (yes vs no)

1.24 (0.71–2.13)

0.435

  

Hypertension (yes vs no)

1.31 (0.83–2.05)

0.247

  

Hyperlipemia (yes vs no)

0.85 (0.54–1.33)

0.468

  

Histological grade (G2/3 vs G1)

1.57 (1.03–2.41)

0.034*

0.92 (0.81–1.22)

0.068

Histological type (serous vs non-serous)

0.49 (0.83–2.64)

0.181

  

FIGO stage (IV vs III)

1.89 (1.17–3.11)

0.014*

1.58 (0.77–3.35)

0.221

ECOG PS (≥1 vs 0)

1.12 (0.74–1.69)

0.603

  

Chemotherapy resistance (yes vs no)

1.27 (1.03–1.62)

0.021*

1.30 (1.01–1.67)

0.032*

Residual tumor (> 1 cm vs ≤1 cm)

1.32 (1.04–1.68)

0.022*

1.48 (1.01–2.21)

0.046*

Hemoglobin (high vs low)

0.78 (0.39–1.56)

0.478

  

Platelet (high vs low)

1.55 (0.75–3.18)

0.237

  

WBC (high vs low)

1.39 (0.77–2.51)

0.278

  

Albumin (high vs low)

0.65 (0.38–1.12)

0.112

  

Total protein (high vs low)

0.89 (0.55–1.45)

0.642

  

Total cholesterol (high vs low)

0.69 (0.31–1.52)

0.359

  

Triglyceride (high vs low)

1.50 (0.83–2.73)

0.181

  

CA125 (high vs low)

1.41 (0.73–2.73)

0.304

  

CRP (high vs low)

1.17 (0.64–2.11)

0.613

  

AFR (≤7.78 vs > 7.78)

2.50 (1.44–4.09)

0.007*

2.19 (1.18–3.67)

0.021*

  1. EOC, Epithelial ovarian cancer; OS, Orall survival; BMI, Body mass index; FIGO, International Federation of Gynecology and Obstetrics; AFR, Albumin-to-fibrinogen ratio; ECOG PS, Eastern cooperative oncology group performance status; WBC, White blood cell; CRP, C-reactive protein; HR, Hazard ratio; CI, Confidence interval. * P < 0.05.