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Table 4 Risk factors for OS by univariate and multiple Cox analysis

From: Preoperative albumin-to-fibrinogen ratio predicts chemotherapy resistance and prognosis in patients with advanced epithelial ovarian cancer

  Univariate Multivariate
Parameters HR(95% CI) p value HR(95% CI) p value
Age (high vs low) 1.23 (0.84–1.81) 0.304   
BMI (high vs low) 0.53 (0.24–1.15) 0.112   
Current smokers (yes vs no) 1.09 (0.76–1.57) 0.647   
Alcohol (yes vs no) 1.17 (0.82–1.67) 0.384   
Diabetes (yes vs no) 1.24 (0.71–2.13) 0.435   
Hypertension (yes vs no) 1.31 (0.83–2.05) 0.247   
Hyperlipemia (yes vs no) 0.85 (0.54–1.33) 0.468   
Histological grade (G2/3 vs G1) 1.57 (1.03–2.41) 0.034* 0.92 (0.81–1.22) 0.068
Histological type (serous vs non-serous) 0.49 (0.83–2.64) 0.181   
FIGO stage (IV vs III) 1.89 (1.17–3.11) 0.014* 1.58 (0.77–3.35) 0.221
ECOG PS (≥1 vs 0) 1.12 (0.74–1.69) 0.603   
Chemotherapy resistance (yes vs no) 1.27 (1.03–1.62) 0.021* 1.30 (1.01–1.67) 0.032*
Residual tumor (> 1 cm vs ≤1 cm) 1.32 (1.04–1.68) 0.022* 1.48 (1.01–2.21) 0.046*
Hemoglobin (high vs low) 0.78 (0.39–1.56) 0.478   
Platelet (high vs low) 1.55 (0.75–3.18) 0.237   
WBC (high vs low) 1.39 (0.77–2.51) 0.278   
Albumin (high vs low) 0.65 (0.38–1.12) 0.112   
Total protein (high vs low) 0.89 (0.55–1.45) 0.642   
Total cholesterol (high vs low) 0.69 (0.31–1.52) 0.359   
Triglyceride (high vs low) 1.50 (0.83–2.73) 0.181   
CA125 (high vs low) 1.41 (0.73–2.73) 0.304   
CRP (high vs low) 1.17 (0.64–2.11) 0.613   
AFR (≤7.78 vs > 7.78) 2.50 (1.44–4.09) 0.007* 2.19 (1.18–3.67) 0.021*
  1. EOC, Epithelial ovarian cancer; OS, Orall survival; BMI, Body mass index; FIGO, International Federation of Gynecology and Obstetrics; AFR, Albumin-to-fibrinogen ratio; ECOG PS, Eastern cooperative oncology group performance status; WBC, White blood cell; CRP, C-reactive protein; HR, Hazard ratio; CI, Confidence interval. * P < 0.05.