Author, year (Refs.) | Strain & treatment | Gestational day of treatment group(s) & (age of sampling) | Results | ||||
---|---|---|---|---|---|---|---|
Ovarian morphological histology | Hormonal profile | Estrus cycle, vaginal opening | Body weight | Metabolic disturbances | |||
Chen et al., 1981 [22] | SD, Feeding by 50% galactose, | Grp 1 or prenatal Grp: 3rd to birth (at birth) Grp 2 or pre & postnatal Grp: 3rd to weaning (after weaning) Grp 3 or postnatal Grp: birth to weaning (after weaning) Grp 4 or post weaning Grp: 1–2 month (at 2 months) S-Grp 1:1st-9th (9th) S-Grp 2: 15th -20th S-Grp 3: entire gestational period S-Grp 4: 1st to weaning (Adv): pre and postnatal study | Grp1: there were no survivor Grp2:SF↓ (about 80%) Grp3:NSD in SF Grp4: MF & LF↓ S-Grp1:SF↓, MF NSD, LF NSD S-Grp2:SF↓, MF NSD, LF NSD S-grp3: SF↓, MF S-Grp 4: SF↓, MF NSD, LF NSD (about 50%) | NR (Lim) | S-Grp 1: DVO (+) S-Grp 2: DVO(−) S-Grp 3: NR S-Grp 4: NR | Grp 1:↓ Grp2: ↓↓ Grp3:↓↓ Grp4:less dramatic BW changes (+) | Grp1:GAL (+) Grp1:Gal-1-p (+) Grp3: GAL less than Grp 1 Grp3: Gal-1-p less than Grp 1 Control group: GAL & Gal-1-p undetectable |
Bandyopadhyay et al., 2003 [23] | SD, Feeding by 35% galactose | Grp1: feeding GAL from 3rd through parturition (12–15 days of gestation from one uterine horn) Grp 2: feeding GAL from 3rd through parturition (PND 1 or 2) | Grp1: PGC↓ | NR (Lim) | NR | NR | Grp 2: Liver epimerase activity ↓ |
Bandyopadhyay et al., 2003 [14] | SD, Grp1:, Feeding by 35% galactose Grp2: Feeding by 35% galactose and followed ovarian stimulating by PMSG-HCG between PND25/30, Grp3: Feeding by 35% galactose and followed desensitized by GnRH and induction after 10 days by PMSG-HCG | Feeding GAL from 3rd day of conception through weaning (PND21, 25/30, 42/43, 70/71) | AF absence CL absence SF↓ ATF↑ | E2, PND 21↓ E2, PND 42/43↓ FSH, PND 21↑ FSH,PND 42/43↑ | Delay VO(+) | Low BW, PND21: (+) GR, PND30/40: ↓ | GAL: (PND21)↑ Gal-1-p: (PND21)↑ GAL: (PND70/71)↑ Gal-1-p: (PND70/71) ↑ |
Banerjee et al. 2012 [24] | SD, Grp 1: Feeding by 35% galactose, (PND 35) Grp 2: Feeding by 35% galactose, received subcutaneous (s.c.) injection of DES (2 mg/rat/day) for 4 days, or PMSG (25 mIU/rat/day) for 2 days. (PND 39–40) | Feeding from 3rd day of gestation and continuing through weaning of the litters. | Grp 1:ATF↑, bio activity GC: NC | Grp 1: FSH bioactivity↓ | NR (Lim) | NR | Grp 1: GalTase ↓ |