Fig. 1
From: Clarithromycin synergizes with cisplatin to inhibit ovarian cancer growth in vitro and in vivo
The effect of CAM alone or combined with DDP on ovarian cancer cells. a C13* and SKOV3 cells were treated with different concentrations of CAM for 48 h, and cell viability was assessed by CCK-8. b and c CCK-8 assay indicated that cell viability was significantly reduced in the CAM plus DDP group compared to the group treated with DDP alone in C13* and SKOV3 cells treated with different concentrations for 48 h. The concentration of CAM used in C13* and SKOV3 cells were 66 μM and 44 μM separately. d and e The combination index (CI) was used to calculate the synergistic effects displayed by the two-drug combination. The data indicated that CAM and DDP synergistically inhibited the growth of C13* and SKOV3 cells. CI values below 1.0 represented synergistic interactions of the two drugs