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Table 1 Literature review of LCNEC of FIGO stage I and II or undecided

From: Role of diagnostic laparoscopy in patients with large cell neuroendocrine carcinoma of the ovary with cancerous peritonitis: case report and review of the literature

Study Age (y) FIGO stage Size (cm) Associated component Metastatic site Ascitic fluid cytology Treatment Outcome
Collins et al., 1991 [4] 34 IC 16 Mucinous cystadenoma & mucinous adenoCa None N/A (bloody 4 l) TAH/BSO/OM + CDDP/CPA DOD 8 months
Khurana et al., 1994 [5] 22 I 21 Mucinous cystadenoma & mucinous adenoCa None N/A RSO/AP + CBDCA + CPA DOD 3 months
Jones et al., 1996 [6] 65 IA 16.5 Mucinous cystadenoma None Negative (1.6 l) TAH/BSO/OM/PLN/AP DOD 10 months
Eichhorn et al., 1996 [7] 77 IA 15 Endometrioid adenoCa grade 1 None N/A TAH/BSO/LN & peritoneal biopsies DOD 19 months
36 IA 10 Mucinous adenoCa None N/A RSO/AP Recent
45 IB 18 Mucinous borderline tumor with small foci of mucinous adenoCa None N/A TAH/BSO/OM + Chem DOD 36 months
68 IIB 9 Mucinous adenoCa Right tube N/A TAH/RSO/OM/peritoneal biopsy Lost to follow-up
Chen, 2000 [8] 44 IA 25 Mucinous intraepithelial adenoCa None N/A TAH/BSO/OM + PTX + CBDCA DOD 4 months
Behnam et al., 2004 [9] 27 IA 17 Pure LCNEC None N/A LSO/right OV & pelvic wall biopsies/PAN//OM/AP + PTX + CBDCA NED 10 months
Hirasawa, 2004 [10] 56 IIC 18 Mucinous adenoCa & dermoid cyst Rectum Positive (adenoCa) TAH/BSO/rectal serosa resection/PLN DOD 10 months
35 IC N/A Mucinous adenoma None N/A TAH/BSO/OM + CDDP (ip) + high-dose Chem NED 10 years
Ohira et al., 2004 [11] 33 IC 11 Endometrioid adenoCa grade 1 None Ruptured LSO/right OV biopsy/OM + CPT-11/Nedaplatin DOD 6 months
Ahmed et al., 2005 [12] 31 N/A 15 Mucinous cystadenoma N/A N/A N/A N/A
Lindboe, 2007 [13] 64 IA 14 Pure LCNEC None Negative TAH/BSO/OM + Bleomycin/CDDP/Etoposide NED 9 months
Veras et al., 2007 [14] 55 I 26 Mucinous low malignant potential with intraepithelial Ca N/A N/A TAH/BSO + platinum-based Chem NED 68 months
54 I 14 Mucinous & endometrioid Ca N/A N/A TAH/BSO + platinum-based Chem NED 66 months
59 I 14 High-grade adenoCa, not otherwise specified N/A N/A BSO + platinum-based Chem NED 28 months
22 I 21 Mucinous low malignant potential with mucinous Ca N/A N/A RSO/AP + platinum-based Chem DOD 3 months
Tartaglia et al., 2008 [15] 56 IIA 8 Pure LCNEC Endometrium Negative TAH/BSO/pelvic wall biopsies/OM/AP/PAN + PTX/CBDCA NED 10 months
Aslam et al., 2009 [16] 76 IIB 30 Pure LCNEC Douglas pouch N/A TAH/BSO/OM/AP/PLN/PAN/Douglas pouch resection DOD post operation
Chenevert et al., 2009 [17] 53 I 21 Mucinous adenoCa & dermoid cyst None N/A TAH/BSO/OM/PLN + CDDP/etoposide DOD 7 months
Oshita et al., 2011 [18] 80 IIC 7 Endometrioid adenoCa Left tube, parametrium Ruptured TAH/BSO/PLN/OM /AP + PTX + CBDCA NED 40 months
65 IC 11 Endometrioid adenoCa with squamous differentiation None Ruptured TAH/BSO/OM + PTX/CBDCA DOD 2 months
Lee et al., 2012 [19] 40 IA 30 Mucinous Ca None N/A TAH/BSO/RPLN/OM/AP + PTX/CBDCA NED 8 months
Ki et al., 2014 [20] 58 IA N/A Pure LCNEC None N/A TAH/BSO/OM/PLN + PTX/CDDP DOD 17 months
67 IIB 13 Pure LCNEC Pelvic peritoneum N/A TAH/BSO/RPLN/OM + PTX/CBDCA NED 5 months
Asada et al., 2014 [21] 50 IA 15 Mucinous adenoma None N/A TAH/BSO/PLN/OM + etoposide/CDDP DOD 7 months
Ding et al., 2014 [22] 70 IA 16 Borderline mucinous tumor None N/A TAH/BSO/PLN/OM/AP NED 6 months
Sehouli et al., 2016 [23] 23 II N/A N/A N/A N/A TAH/BSO/RPLN/OM/AP/colon resection + PTX/CBDCA NED 111 months
61 I N/A N/A N/A N/A TAH/BSO NED 37 months
Doganay et al., 2019 [24] 73 II 10 Pure LCNEC Uterus, bladder, rectum Positive (malignant cells) TAH/BSO/pelvic mass resection + etoposide/CDDP AEW 6 months