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Table 1 Literature review of LCNEC of FIGO stage I and II or undecided

From: Role of diagnostic laparoscopy in patients with large cell neuroendocrine carcinoma of the ovary with cancerous peritonitis: case report and review of the literature

Study

Age (y)

FIGO stage

Size (cm)

Associated component

Metastatic site

Ascitic fluid cytology

Treatment

Outcome

Collins et al., 1991 [4]

34

IC

16

Mucinous cystadenoma & mucinous adenoCa

None

N/A (bloody 4 l)

TAH/BSO/OM + CDDP/CPA

DOD 8 months

Khurana et al., 1994 [5]

22

I

21

Mucinous cystadenoma & mucinous adenoCa

None

N/A

RSO/AP + CBDCA + CPA

DOD 3 months

Jones et al., 1996 [6]

65

IA

16.5

Mucinous cystadenoma

None

Negative (1.6 l)

TAH/BSO/OM/PLN/AP

DOD 10 months

Eichhorn et al., 1996 [7]

77

IA

15

Endometrioid adenoCa grade 1

None

N/A

TAH/BSO/LN & peritoneal biopsies

DOD 19 months

36

IA

10

Mucinous adenoCa

None

N/A

RSO/AP

Recent

45

IB

18

Mucinous borderline tumor with small foci of mucinous adenoCa

None

N/A

TAH/BSO/OM + Chem

DOD 36 months

68

IIB

9

Mucinous adenoCa

Right tube

N/A

TAH/RSO/OM/peritoneal biopsy

Lost to follow-up

Chen, 2000 [8]

44

IA

25

Mucinous intraepithelial adenoCa

None

N/A

TAH/BSO/OM + PTX + CBDCA

DOD 4 months

Behnam et al., 2004 [9]

27

IA

17

Pure LCNEC

None

N/A

LSO/right OV & pelvic wall biopsies/PAN//OM/AP + PTX + CBDCA

NED 10 months

Hirasawa, 2004 [10]

56

IIC

18

Mucinous adenoCa & dermoid cyst

Rectum

Positive (adenoCa)

TAH/BSO/rectal serosa resection/PLN

DOD 10 months

35

IC

N/A

Mucinous adenoma

None

N/A

TAH/BSO/OM + CDDP (ip) + high-dose Chem

NED 10 years

Ohira et al., 2004 [11]

33

IC

11

Endometrioid adenoCa grade 1

None

Ruptured

LSO/right OV biopsy/OM + CPT-11/Nedaplatin

DOD 6 months

Ahmed et al., 2005 [12]

31

N/A

15

Mucinous cystadenoma

N/A

N/A

N/A

N/A

Lindboe, 2007 [13]

64

IA

14

Pure LCNEC

None

Negative

TAH/BSO/OM + Bleomycin/CDDP/Etoposide

NED 9 months

Veras et al., 2007 [14]

55

I

26

Mucinous low malignant potential with intraepithelial Ca

N/A

N/A

TAH/BSO + platinum-based Chem

NED 68 months

54

I

14

Mucinous & endometrioid Ca

N/A

N/A

TAH/BSO + platinum-based Chem

NED 66 months

59

I

14

High-grade adenoCa, not otherwise specified

N/A

N/A

BSO + platinum-based Chem

NED 28 months

22

I

21

Mucinous low malignant potential with mucinous Ca

N/A

N/A

RSO/AP + platinum-based Chem

DOD 3 months

Tartaglia et al., 2008 [15]

56

IIA

8

Pure LCNEC

Endometrium

Negative

TAH/BSO/pelvic wall biopsies/OM/AP/PAN + PTX/CBDCA

NED 10 months

Aslam et al., 2009 [16]

76

IIB

30

Pure LCNEC

Douglas pouch

N/A

TAH/BSO/OM/AP/PLN/PAN/Douglas pouch resection

DOD post operation

Chenevert et al., 2009 [17]

53

I

21

Mucinous adenoCa & dermoid cyst

None

N/A

TAH/BSO/OM/PLN + CDDP/etoposide

DOD 7 months

Oshita et al., 2011 [18]

80

IIC

7

Endometrioid adenoCa

Left tube, parametrium

Ruptured

TAH/BSO/PLN/OM /AP + PTX + CBDCA

NED 40 months

65

IC

11

Endometrioid adenoCa with squamous differentiation

None

Ruptured

TAH/BSO/OM + PTX/CBDCA

DOD 2 months

Lee et al., 2012 [19]

40

IA

30

Mucinous Ca

None

N/A

TAH/BSO/RPLN/OM/AP + PTX/CBDCA

NED 8 months

Ki et al., 2014 [20]

58

IA

N/A

Pure LCNEC

None

N/A

TAH/BSO/OM/PLN + PTX/CDDP

DOD 17 months

67

IIB

13

Pure LCNEC

Pelvic peritoneum

N/A

TAH/BSO/RPLN/OM + PTX/CBDCA

NED 5 months

Asada et al., 2014 [21]

50

IA

15

Mucinous adenoma

None

N/A

TAH/BSO/PLN/OM + etoposide/CDDP

DOD 7 months

Ding et al., 2014 [22]

70

IA

16

Borderline mucinous tumor

None

N/A

TAH/BSO/PLN/OM/AP

NED 6 months

Sehouli et al., 2016 [23]

23

II

N/A

N/A

N/A

N/A

TAH/BSO/RPLN/OM/AP/colon resection + PTX/CBDCA

NED 111 months

61

I

N/A

N/A

N/A

N/A

TAH/BSO

NED 37 months

Doganay et al., 2019 [24]

73

II

10

Pure LCNEC

Uterus, bladder, rectum

Positive (malignant cells)

TAH/BSO/pelvic mass resection + etoposide/CDDP

AEW 6 months