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Table 2 Literature review of LCNEC of FIGO stage III and IV

From: Role of diagnostic laparoscopy in patients with large cell neuroendocrine carcinoma of the ovary with cancerous peritonitis: case report and review of the literature

Study

Age (y)

FIGO stage

Size (cm)

Associated component

Metastatic site

Ascitic fluid cytology

Treatment

Outcome

Eichhorn et al., 1996 [7]

58

IIIB

30

Mucinous borderline tumor with small foci of mucinous adenoCa

Appendix, peritoneum

N/A

TAH/BSO/OM/AP/LN & peritoneal biopsies + Chem

DOD 8 months

Chen, 2000 [8]

73

IIIC

11

Microinvasive mucinous adenoCa

Small bowel serosa, retroperitoneal LN

N/A

BSO/OM/RPLN+ PTX/CDDP

DOD 8 months

Choi et al., 2007 [25]

71

IIIB

6.5

Serous Ca

Retroperitoneum

N/A

TAH/BSO + PTX/CBDCA

NED 8 months

Veras et al., 2007 [14]

39

IV

26

Mucinous adenoCa

N/A

N/A

TAH/BSO + platinum-based Chem

AWD 8 months

42

IV

N/A

Benign cyst & dermoid cyst in contralateral OV

N/A

N/A

TAH/BSO + platinum-based Chem

DOD 20 months

53

III

14.5

Endometrioid adenoCa

N/A

N/A

TAH/BSO + platinum-based Chem

NED 37 months

47

III

14

AdenoCa, not otherwise specified & mature teratoma

N/A

N/A

TAH/BSO + platinum-based Chem

NED 11 months

25

IV

5

Mature cystic teratoma

N/A

N/A

BSO/OM/AP + platinum-based Chem

DOD 36 months

55

III

13.5

Mucinous low malignant potential

N/A

N/A

TAH/BSO + platinum-based Chem

DOD 2 months

63

IV

14

Endometrioid adenoCa

N/A

N/A

TAH/RSO + platinum-based Chem

DOD 9 months

Tsuji et al., 2008 [26]

46

IIIC

12

Squamous differentiation

Omentum, peritoneum, rectum, uterus

N/A (bloody 2 l)

subTAH/BSO/OM + PTX/CBDCA

DOD 4 months

Dundr et al., 2008 [27]

73

IV

9

Pure LCNEC

Mesentery, left renal capsule, CNS

N/A

CNS meta resection/γ Knife + TAH/BSO/OM/mesenterial meta resection/left nephrectomy + PTX/CBDCA + γ Knife

NED 12 months

Chenevert et al., 2009 [17]

53

20

IV

Mucinous adenoCa

Douglas pouch, lungs, mediastinal LN, liver, bone

N/A

TAH/BSO/OM/PLN/Douglas pouch resection + PTX/CBDCA

DOD 3 months

Yasuoka et al., 2009 [28]

36

26

IIIA1

Mucinous intraepithelial Ca

Periaortic LN

N/A

TAH/BSO/RPLN/OM + Chem

NED 6 months

Draganova-Tacheva et al., 2009 [29]

68

IV

18

Serous Ca

Peritoneum, omentum, uterus, bladder, colon, diaphragm, inguinal LNs

Positive (papillary serous adenoCa)

NAC (PTX/CBDCA) + IDS (BSO/OM) + PTX/CBDCA

DOD 7 months

Oshita et al., 2011 [18]

66

IV

11

N/A

Vagina, lungs

N/A

NAC (PTX/CBDCA) + IDS (TAH/BSO/OM/peritoneal biopsy) + PTX/CBDCA + brain meta resection & RT

NED 64 months

42

IIIB

13

Endometrioid adenoCa

Peritoneum

N/A

TAH/BSO/RPLN/OM/Douglas pouch resection+ PTX/CBDCA

NED 32 months

Miyamoto et al., 2012 [30]

69

IV

15

Mature cystic teratoma

Peritoneum, lungs, retroperitoneal & subclavian LNs

Ruptured

LSO/RPLN/subclavian LN biopsies + PTX/CBDCA

DOD 6 months

Shakuntala et al., 2012 [31]

40

IIIC

20

Pure LCNEC

Omentum, paraaortic LN, bowel, bladder

N/A (minimal bloody)

BSO/OM/PAN/bladder & sigmoid colon deposit resection + CDDP/etoposide

NED 6 months

Ki et al., 2014 [20]

77

IV

15

Pure LCNEC

Supraclavicular LN

Positive (malignant cells)

TAH/pelvic & neck masses resection + etoposide/CBDCA

DOD 45 days

Cokmert et al., 2014 [32]

68

IV

20

AdenoCa

Uterus, bladder, sigmoid colon, omentum, lungs mediastinum LN, bones

N/A

TAH/BSO/RPLN/OM + RT

DOD 7 months

Lin et al., 2014 [33]

50

IV

25

Pure LCNEC

Liver, pelvic wall, intestine, left tube, parametrium, omentum, appendix

N/A

TAH/BSO/OM + PTX/CBDCA

DOD 3 months

Agarwal et al., 2016 [34]

35

IIIC

6

Pure LCNEC

Cervix, retroperitoneal LN

Negative

TAH + BSO

AWD 3 months

Herold et al., 2018 [35]

75

IV

13

Pure LCNEC

Pelvic peritoneum, retroperitoneal LN, liver

N/A

Laparoscopy → BSO/RPLN/OM/pelvic peritoneum & liver resection + etoposide/CBDCA + PTX/CBDCA

NED 36 months

Present

31

IIIC

10

Pure LCNEC

Peritoneum, omentum

Negative (bloody 7 l)

Diagnostic laparoscopy + etoposide/CDDP

DOD 3 months

  1. LCNEC large cell neuroendocrine carcinoma, Ca carcinoma, FIGO International Federation of Gynecology and Obstetrics, TAH total abdominal hysterectomy, BSO bilateral salpingo-oophorectomy, RSO right salpingo-oophorectomy, LSO left salpingo-oophorectomy, RPLN retroperitoneal lymphadenectomy, PLN pelvic lymphadenectomy, PAN para-aortic lymphadenectomy, OM omentectomy, AP appendectomy, IDS interval debulking surgery, OV ovary, LN lymph node, CNS central nervous system, meta metastasis, RT radiation, Chem chemotherapy, CDDP cisplatin, CPA cyclophosphamide, CBDCA carboplatin, PTX paclitaxel, ADR adriamycin, CPT-11 irinotecan, NAC neoadjuvant chemotherapy, ip intraperitoneal, DOD dead of disease, NED: no evidence of disease, AWD alive with disease, N/A no information available