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Table 2 Literature review of LCNEC of FIGO stage III and IV

From: Role of diagnostic laparoscopy in patients with large cell neuroendocrine carcinoma of the ovary with cancerous peritonitis: case report and review of the literature

Study Age (y) FIGO stage Size (cm) Associated component Metastatic site Ascitic fluid cytology Treatment Outcome
Eichhorn et al., 1996 [7] 58 IIIB 30 Mucinous borderline tumor with small foci of mucinous adenoCa Appendix, peritoneum N/A TAH/BSO/OM/AP/LN & peritoneal biopsies + Chem DOD 8 months
Chen, 2000 [8] 73 IIIC 11 Microinvasive mucinous adenoCa Small bowel serosa, retroperitoneal LN N/A BSO/OM/RPLN+ PTX/CDDP DOD 8 months
Choi et al., 2007 [25] 71 IIIB 6.5 Serous Ca Retroperitoneum N/A TAH/BSO + PTX/CBDCA NED 8 months
Veras et al., 2007 [14] 39 IV 26 Mucinous adenoCa N/A N/A TAH/BSO + platinum-based Chem AWD 8 months
42 IV N/A Benign cyst & dermoid cyst in contralateral OV N/A N/A TAH/BSO + platinum-based Chem DOD 20 months
53 III 14.5 Endometrioid adenoCa N/A N/A TAH/BSO + platinum-based Chem NED 37 months
47 III 14 AdenoCa, not otherwise specified & mature teratoma N/A N/A TAH/BSO + platinum-based Chem NED 11 months
25 IV 5 Mature cystic teratoma N/A N/A BSO/OM/AP + platinum-based Chem DOD 36 months
55 III 13.5 Mucinous low malignant potential N/A N/A TAH/BSO + platinum-based Chem DOD 2 months
63 IV 14 Endometrioid adenoCa N/A N/A TAH/RSO + platinum-based Chem DOD 9 months
Tsuji et al., 2008 [26] 46 IIIC 12 Squamous differentiation Omentum, peritoneum, rectum, uterus N/A (bloody 2 l) subTAH/BSO/OM + PTX/CBDCA DOD 4 months
Dundr et al., 2008 [27] 73 IV 9 Pure LCNEC Mesentery, left renal capsule, CNS N/A CNS meta resection/γ Knife + TAH/BSO/OM/mesenterial meta resection/left nephrectomy + PTX/CBDCA + γ Knife NED 12 months
Chenevert et al., 2009 [17] 53 20 IV Mucinous adenoCa Douglas pouch, lungs, mediastinal LN, liver, bone N/A TAH/BSO/OM/PLN/Douglas pouch resection + PTX/CBDCA DOD 3 months
Yasuoka et al., 2009 [28] 36 26 IIIA1 Mucinous intraepithelial Ca Periaortic LN N/A TAH/BSO/RPLN/OM + Chem NED 6 months
Draganova-Tacheva et al., 2009 [29] 68 IV 18 Serous Ca Peritoneum, omentum, uterus, bladder, colon, diaphragm, inguinal LNs Positive (papillary serous adenoCa) NAC (PTX/CBDCA) + IDS (BSO/OM) + PTX/CBDCA DOD 7 months
Oshita et al., 2011 [18] 66 IV 11 N/A Vagina, lungs N/A NAC (PTX/CBDCA) + IDS (TAH/BSO/OM/peritoneal biopsy) + PTX/CBDCA + brain meta resection & RT NED 64 months
42 IIIB 13 Endometrioid adenoCa Peritoneum N/A TAH/BSO/RPLN/OM/Douglas pouch resection+ PTX/CBDCA NED 32 months
Miyamoto et al., 2012 [30] 69 IV 15 Mature cystic teratoma Peritoneum, lungs, retroperitoneal & subclavian LNs Ruptured LSO/RPLN/subclavian LN biopsies + PTX/CBDCA DOD 6 months
Shakuntala et al., 2012 [31] 40 IIIC 20 Pure LCNEC Omentum, paraaortic LN, bowel, bladder N/A (minimal bloody) BSO/OM/PAN/bladder & sigmoid colon deposit resection + CDDP/etoposide NED 6 months
Ki et al., 2014 [20] 77 IV 15 Pure LCNEC Supraclavicular LN Positive (malignant cells) TAH/pelvic & neck masses resection + etoposide/CBDCA DOD 45 days
Cokmert et al., 2014 [32] 68 IV 20 AdenoCa Uterus, bladder, sigmoid colon, omentum, lungs mediastinum LN, bones N/A TAH/BSO/RPLN/OM + RT DOD 7 months
Lin et al., 2014 [33] 50 IV 25 Pure LCNEC Liver, pelvic wall, intestine, left tube, parametrium, omentum, appendix N/A TAH/BSO/OM + PTX/CBDCA DOD 3 months
Agarwal et al., 2016 [34] 35 IIIC 6 Pure LCNEC Cervix, retroperitoneal LN Negative TAH + BSO AWD 3 months
Herold et al., 2018 [35] 75 IV 13 Pure LCNEC Pelvic peritoneum, retroperitoneal LN, liver N/A Laparoscopy → BSO/RPLN/OM/pelvic peritoneum & liver resection + etoposide/CBDCA + PTX/CBDCA NED 36 months
Present 31 IIIC 10 Pure LCNEC Peritoneum, omentum Negative (bloody 7 l) Diagnostic laparoscopy + etoposide/CDDP DOD 3 months
  1. LCNEC large cell neuroendocrine carcinoma, Ca carcinoma, FIGO International Federation of Gynecology and Obstetrics, TAH total abdominal hysterectomy, BSO bilateral salpingo-oophorectomy, RSO right salpingo-oophorectomy, LSO left salpingo-oophorectomy, RPLN retroperitoneal lymphadenectomy, PLN pelvic lymphadenectomy, PAN para-aortic lymphadenectomy, OM omentectomy, AP appendectomy, IDS interval debulking surgery, OV ovary, LN lymph node, CNS central nervous system, meta metastasis, RT radiation, Chem chemotherapy, CDDP cisplatin, CPA cyclophosphamide, CBDCA carboplatin, PTX paclitaxel, ADR adriamycin, CPT-11 irinotecan, NAC neoadjuvant chemotherapy, ip intraperitoneal, DOD dead of disease, NED: no evidence of disease, AWD alive with disease, N/A no information available