Fig. 1

A schematic diagram of the JNK signaling pathway promoting cell death in ovarian cancer. a Endoplasmic reticulum stress (ER), reactive oxygen species (ROS), and the Akt signaling pathway can regulate IER1 alpha, UPR and A SK1, thereby activating MKKK4/7 to regulate JNK signaling pathway activity, leading to autophagic cell death, mitochondrial pathway-mediated cell death and AP-1-induced apoptosis. Death-related antibodies mediate cell death. In addition, the JNK signaling pathway can regulate the expression of P27/P21 and cause cell cycle arrest. b SiRNA and the JNK related inhibitor WBZ_4, inhibit JNK1 expression and cell proliferation. c The JNK inhibitor SP600458 affects the JNK signaling pathway and destroys MMP, thereby enhancing the expression of PARP1 and Caspase-3 and, therefore, promoting cell death