Fig. 3

Withaferin A ameliorates myofiber size reduction in ovarian cancer-induced cachexia. (a) Representative images of H&E stained GA and QF transverse muscle sections. (b) Quantification of average myofiber cross-sectional area (CSA). Scale Bar = 50 μm. N = 5 (control), 4 (vehicle treated), 5 (WFA 2 mg/kg), and 4 (WFA 6 mg/kg). Opaque black circles indicate individual data points. *P < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001, value significantly different from corresponding value of control mice as determined by one-way ANOVA followed by Tukey’s HSDT. #P < 0.05, value significantly different from corresponding value of vehicle treated group. $P < 0.05, value significantly different from corresponding value of WFA 2 mg/kg group