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Fig. 4 | Journal of Ovarian Research

Fig. 4

From: Withaferin A ameliorates ovarian cancer-induced cachexia and proinflammatory signaling

Fig. 4

Withaferin A inhibits a slow to fast fiber-type conversion in ovarian cancer. (a) Representative images of transverse TA muscle sections from control, vehicle treated, WFA 2 mg/kg, and WFA 6 mg/kg mice subjected to triple immunostaining against MyHC I (blue color), IIa (red color), and IIb (green color) proteins. Unstained fibers were considered to be Type IIx. Scale Bar = 50 μm. (b) Quantification of the percentage of Type I, Type IIa, Type IIx, and Type IIb myofibers in TA muscle. (c) Relative mRNA levels of select inflammatory cytokines in TA muscle. N = 4 in each group. Opaque black circles indicate individual data points. *P < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001, value significantly different from corresponding value of control group as determined by one-way ANOVA followed by Tukey’s HSDT. #P < 0.05, value significantly different from corresponding value of vehicle treated group. $P < 0.05, value significantly different from corresponding value of WFA 2 mg/kg group

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