Development and validation of circulating CA125 prediction models in postmenopausal women

Table 2 Linear CA125 prediction model in Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO) training dataset

Predictor	% Change in CA125 levels ^c	p-value
Age ^a (per year)	0.5	< 0.0001
Race
White	Ref	Ref
Black	−20.7	< 0.0001
Hispanic	−12.0	< 0.0001
Asian	−8.5	< 0.0001
Other	−11.4	0.005
Body Mass Index ^b (per kg/m²)	−0.4	< 0.0001
Smoking status
Never	Ref	Ref
Current	−16.9	< 0.0001
Former	0.5	0.60
Pack-years among current smokers	0.2	0.001
Pack-years among former smokers	0.1	0.02
Parity (per child)	0.9	0.0001
Hysterectomy	−11.2	< 0.0001
Age at last menstrual period
< 40 years	−2.5	0.08
40–44 years	−1.7	0.18
45–49 years	−0.6	0.53
50–54 years	Ref	Ref
≥ 55 years	4.6	0.0001
Hormone therapy
Never	Ref	Ref
Ever	2.1	0.85
Duration of hormone therapy
0 years	Ref	Ref
≤ 1 year	−0.04	0.99
2–3 years	1.7	0.88
4–5 years	1.7	0.88
6–9 years	2.4	0.83
≥ 10 years	4.2	0.71
R-square	0.05

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