Table 3 Summary of Adverse Events
Adverse Event | Any Grade | Grade 3 or 4 |
|---|---|---|
number of patients (percent) | ||
Fatigue or asthenia | 17 (60.7) | 0 (0) |
Anemia | 12 (42.9) | 3 (10.7) |
Decreased appetite | 12 (42.9) | 0 (0) |
Nausea | 11 (39.3) | 0 (0) |
Arthralgia | 9 (32.1) | 0 (0) |
Vomiting | 7 (25.0) | 0 (0) |
Abdominal pain | 5 (17.9) | 2 (7.1) |
Constipation | 5 (17.9) | 0 (0) |
Dysgeusia | 5 (17.9) | 0 (0) |
Neutropenia | 5 (17.9) | 0 (0) |
Thrombocytopenia | 4 (14.3) | 1 (3.6) |
Back pain | 4 (14.3) | 0 (0) |
Diarrhea | 3 (10.7) | 0 (0) |
Dizziness | 3 (10.7) | 0 (0) |
Upper abdominal pain | 3 (10.7) | 0 (0) |
Cough | 3 (10.7) | 0 (0) |
Dyspnea | 1 (3.6) | 0 (0) |
Headache | 0 (0) | 0 (0) |
Dyspepsia | 0 (0) | 0 (0) |
Newly observed | ||
Abdominal distention | 4 (14.3) | 0 (0) |
Decreased blood pressure | 1 (3.6) | 0 (0) |
Skin rash | 1 (3.6) | 0 (0) |
Increased body hair | 1 (3.6) | 0 (0) |
Thirsty | 1 (3.6) | 0 (0) |
Burning sensation of stomach | 1 (3.6) | 0 (0) |
Leg swelling | 1 (3.6) | 0 (0) |
Led to discontinuation of intervention | 3 (10.7) | – |
Led to dose reduction | 8 (28.6) | – |
Led to dose interruption | 4 (14.3) | – |