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Table 1 Regulation of the Wnt/β-catenin signaling pathway by miRNAs in EOC

From: Wnt/β-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis

miRNATargetsExpression in EOCEffects on EOCEffects on β-catenin activityReference
miR-27aFOXO1IncreasedPromote EMT in ovarian cancerActivate[98]
miR-126-5pAXIN1, DKK3N.DPromote platinum resistanceActivate[99]
miR-92aDKK1IncreasedPromote stemness and chemoresistanceActivate[100]
miR-762MEN1IncreasedPromote proliferation, migration and invasion and inhibit apoptosisActivate[101]
miR-197NLKIncreasedPromote taxol resistanceActivate[102]
miR-939APC2IncreasedPromote proliferation and anchorage-independent growthActivate[103]
miR-1207SFRP1, AXIN2, ICATIncreasedPromote cancer stem-like traitActivate[104]
miR-16NDDecreasedInhibit proliferation, migration and invasionSuppress[105]
miR-340FHL2DecreasedInhibit proliferation and metastasisSuppress[106]
miR-34cSOX9DecreasedInhibit proliferation and cisplatin chemoresistanceSuppress[107]
miR-377CUL4ADecreasedInhibit cell proliferationSuppress[108]
miR-370FOXM1DecreasedInhibit proliferation and metastasisSuppress[109]
miR-214NDDecreasedInhibit proliferation and invasionSuppress[110]
miR-219-5pTWIST1DecreasedInhibit proliferation, migration, and invasionSuppress[111]
miR-152WNT1, ADAM17DecreasedInhibit EMT, migration, and invasionSuppress[112]
miR-133a-3pNDDecreasedInhibit proliferation and invasionSuppress[113]
miR-429KIAA0101DecreasedInhibit cell migration, invasion and cisplatin resistanceSuppress[114]
miR-381YY1DecreasedInhibit proliferation and migrationSuppress[115]
miR-15bWNT7ADecreasedDecrease adhesion and invasionSuppress[116]
miR-101MARCH7, ZEB1, ZEB2DecreasedInhibit proliferation, migration, and invasionSuppress[117,118,119]