Table 1 Regulation of the Wnt/β-catenin signaling pathway by miRNAs in EOC
miRNA | Targets | Expression in EOC | Effects on EOC | Effects on β-catenin activity | Reference |
|---|---|---|---|---|---|
miR-27a | FOXO1 | Increased | Promote EMT in ovarian cancer | Activate | [98] |
miR-126-5p | AXIN1, DKK3 | N.D | Promote platinum resistance | Activate | [99] |
miR-92a | DKK1 | Increased | Promote stemness and chemoresistance | Activate | [100] |
miR-762 | MEN1 | Increased | Promote proliferation, migration and invasion and inhibit apoptosis | Activate | [101] |
miR-197 | NLK | Increased | Promote taxol resistance | Activate | [102] |
miR-939 | APC2 | Increased | Promote proliferation and anchorage-independent growth | Activate | [103] |
miR-1207 | SFRP1, AXIN2, ICAT | Increased | Promote cancer stem-like trait | Activate | [104] |
miR-16 | ND | Decreased | Inhibit proliferation, migration and invasion | Suppress | [105] |
miR-340 | FHL2 | Decreased | Inhibit proliferation and metastasis | Suppress | [106] |
miR-34c | SOX9 | Decreased | Inhibit proliferation and cisplatin chemoresistance | Suppress | [107] |
miR-377 | CUL4A | Decreased | Inhibit cell proliferation | Suppress | [108] |
miR-370 | FOXM1 | Decreased | Inhibit proliferation and metastasis | Suppress | [109] |
miR-214 | ND | Decreased | Inhibit proliferation and invasion | Suppress | [110] |
miR-219-5p | TWIST1 | Decreased | Inhibit proliferation, migration, and invasion | Suppress | [111] |
miR-152 | WNT1, ADAM17 | Decreased | Inhibit EMT, migration, and invasion | Suppress | [112] |
miR-133a-3p | ND | Decreased | Inhibit proliferation and invasion | Suppress | [113] |
miR-429 | KIAA0101 | Decreased | Inhibit cell migration, invasion and cisplatin resistance | Suppress | [114] |
miR-381 | YY1 | Decreased | Inhibit proliferation and migration | Suppress | [115] |
miR-15b | WNT7A | Decreased | Decrease adhesion and invasion | Suppress | [116] |
miR-101 | MARCH7, ZEB1, ZEB2 | Decreased | Inhibit proliferation, migration, and invasion | Suppress |