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Table 3 Univariate and multivariate Cox Proportional hazard ratios (HR) for disease recurrence

From: Interval between secondary cytoreductive surgery and adjuvant chemotherapy is not associated with survivals in patients with recurrent ovarian cancer

 UnivariateMultivariate
HR (95% CI)p-valueHR (95% CI)p-value
Treatment intervala
 Group 11 (reference)   
 Group 21.113 (0.680–1.822)0.670  
Age
 < 65 yr1 (reference)   
 ≥ 65 yr0.679 (0.271–1.701)0.409  
CA-125
 < 40 U/mL1 (reference) 1 (reference) 
 ≥ 40 U/mL1.976 (1.187–3.287)0.0091.620 (0.954–2.749)0.074
Histology
 Serous1 (reference)   
 Non-serous1.081 (0.597–1.956)0.798  
Surgery
 Laparoscopy1 (reference)   
 Laparotomy1.657 (0.900–3.051)0.105  
ASA scoreb
 11 (reference)   
 2, 30.808 (0.458–1.426)0.462  
Residual diseasec
 R01 (reference) 1 (reference) 
 R1, R22.366 (1.384–4.046)0.0022.031 (1.161–3.554)0.013
Platinum free interval
 6-12mo1 (reference) 1 (reference) 
 over 12mo0.509 (0.276–0.940)0.0310.582 (0.309–1.095)0.093
Recurrence no.
 1st recur1 (reference)   
 2nd recur0.967 (0.416–2.247)0.938  
  1. aEnrolled patients were divided into two groups; Group1 (treatment interval ≤ 10 days) and Group2 (treatment interval > 10 days)
  2. bASA score, American Society of Anaesthesiologists score
  3. cThe level of residual disease after SCS was divided into no gross (R0), 1–9 mm (R1), and equal to or more than 10 mm residual disease (R2)