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Table 4 Univariate and multivariate Cox Proportional hazard ratios (HR) for death

From: Interval between secondary cytoreductive surgery and adjuvant chemotherapy is not associated with survivals in patients with recurrent ovarian cancer

 UnivariateMultivariate
HR (95% CI)p-valueHR (95% CI)p-value
Treatment intervala
 Group 11 (reference)   
 Group 20.772 (0.405–1.472)0.433  
Age
 < 65 yr1 (reference)   
 ≥ 65 yr0.202 (0.028–1.479)0.115  
CA-125
 < 40 U/mL1 (reference) 1 (reference) 
 ≥ 40 U/mL2.664 (1.401–5.065)0.0031.930 (0.997–3.776)0.054
Histology
 Serous1 (reference)   
 Non-serous1.820 (0.900–3.682)0.096  
Surgery
 Laparoscopy1 (reference) 1 (reference) 
 Laparotomy3.060 (1.081–8.661)0.0352.572 (0.889–7.438)0.081
ASA scoreb
 11 (reference)   
 2, 31.057 (0.484–2.310)0.889  
Residual diseasec
 R01 (reference) 1 (reference) 
 R1, R23.699 (1.929–7.093)< 0.0013.018 (1.486–6.130)0.002
Platinum free interval
 6-12mo1 (reference) 1 (reference) 
 over 12mo0.462 (0.224–0.954)0.0370.398 (0.180–0.880)0.023
Recurrence no.
 1st recur1 (reference)   
 2nd recur1.277 (0.451–3.619)0.645  
  1. aEnrolled patients were divided into two groups; Group1 (treatment interval ≤ 10 days) and Group2 (treatment interval > 10 days)
  2. bASA score, American Society of Anaesthesiologists score
  3. cThe level of residual disease after SCS was divided into no gross (R0), 1–9 mm (R1), and equal to or more than 10 mm residual disease (R2)