Fig. 2
From: Integrative analysis of transcription factors and microRNAs in ovarian cancer cell spheroids
Integrative network composed of TFs, miRNAs, and target genes. Genes of known function were grouped using dotted lines. Transcription-related genes were most common, while genes of cell cycle and cell adhesion were suppressed in SFCs. EGR1, MYC, and miR-130a-3p were the main regulators to remain as a quiescent phenotype of stem cell. Rectangle: TF, ellipse: gene, diamond: miRNA, colors indicate fold change of the expression in spheroid-forming cells relative to parental cells (red: ≥2, yellow: 2 > to > 1, green: 1 > to ≥0.5, blue: > 0.5), SFC: spheroid-forming cell, TF: transcription factor