Integrative analysis of transcription factors and microRNAs in ovarian cancer cell spheroids

Table 9 Regulators with multiple connections in network and their roles in stem cells

Regulators	Fold change	P-value	Function in tumor	Function in stem cell	Reference
EGR1	2.479	0.045	Tumor suppressor, Chemoresistance enhancer	Promote quiescence	[12], [13], [14]
MYC	0.387	0.036	Proto-oncogene	Inactivation induce quiescence or differentiation	[15, 16]
PBX1	0.759	0.032	Stem cell reprogramming factor, Chemoresistance enhancer	Maintain quiescence	[17, 18]
EP300	1.484	0.005	Tumor suppressor, Chemoresistance modulator	Modulate stemness	[19]
miR-130a-3p	0.381	0.007	Tumor suppressor, Chemoresistance modulator	Target genes maintain quiescence	[20,21,22]