Fig. 1
From: FMRpolyG accumulates in FMR1 premutation granulosa cells
Granulosa cells from FMR1 premutation female carriers demonstrating co-localization of FMRpolyG and ubiquitin. a Fixated and stained granulosa cells from FMR1 premutation female carriers (FMR PM #1–3) displayed FMRpolyG expression and accumulation in ubiquitin-positive cytoplasmic inclusions. Granulosa cells from a non-carrier woman did not show any formation of FMRpolyG or ubiquitin inclusion bodies (CTL) Bar 10 μm. b Immunoblotting using anti-FMRpolyG revealed expression in granulosa cells of FMR1 premutation carriers (59 and 65 CGG repeats respectively) and none in granulosa cells from a non-carrier (CTL)