FMRpolyG accumulates in ubiquitin-positive inclusions in a mouse brain tissue with FXTAS. Paraffin embedded brains from a mouse disease model with 100 CGG repeats and a control mouse with 20 CGG repeats were sectioned and immune-stained. FXTAS mice brain tissue with 100 CGG repeats revealed co-localization of FMRpolyG and ubiquitin inclusions
The control tissue with 20 CGG repeats showed no formation of FMRpolyG or ubiquitin inclusions. Bar 10 μm.