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Table 1 The top platinum-resistance related genes based on text mining

From: Systematic analysis of ovarian cancer platinum-resistance mechanisms via text mining

GeneDescriptionCount
TP53tumor protein p53108
ABCB1ATP binding cassette subfamily B member 164
AKT1AKT serine/threonine kinase 159
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit40
BCL2BCL2, apoptosis regulator28
EGFRepidermal growth factor receptor27
BRCA1BRCA1, DNA repair associated26
PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha25
MAPK1mitogen-activated protein kinase 124
ABCC1ATP binding cassette subfamily C member 122
IL6interleukin 620
NFKB1nuclear factor kappa B subunit 120
STAT3signal transducer and activator of transcription 319
MTORmechanistic target of rapamycin kinase18
PARP1poly (ADP-ribose) polymerase 117
TNFSF10TNF superfamily member 1017
BRCA2BRCA2, DNA repair associated15
HDAC1histone deacetylase 115
TNFtumor necrosis factor15
  1. Only the genes that co-appeared with drug name (such as “cisplatin”) and phenomenons (such as “resistance”) in the same sentence will & be treated