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Table 3 The top nodes (degree> 20) in platinum-resistance related PPI network

From: Systematic analysis of ovarian cancer platinum-resistance mechanisms via text mining

Node

Description

Degree

TP53

tumor protein p53

56

HSP90AA1

heat shock protein 90 alpha family class A member 1

41

ESR1

estrogen receptor 1

40

AKT1

AKT serine/threonine kinase 1

39

BRCA1

BRCA1, DNA repair associated

35

EGFR

epidermal growth factor receptor

34

CTNNB1

catenin beta 1

31

CASP3

caspase 3

30

HDAC1

histone deacetylase 1

28

MAPK1

mitogen-activated protein kinase 1

26

STAT3

signal transducer and activator of transcription 3

26

MAPK8

mitogen-activated protein kinase 8

25

SP1

Sp1 transcription factor

24

GSK3B

glycogen synthase kinase 3 beta

23

CDKN1A

cyclin dependent kinase inhibitor 1A

23

PARP1

poly (ADP-ribose) polymerase 1

22

BCL2

BCL2, apoptosis regulator

21

CASP8

caspase 8

21

  1. All edges are treated as undirected. The degree of each node is calculated with CytoNCA, a plugin for Cytoscape