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Table 3 The top nodes (degree>‚ÄČ20) in platinum-resistance related PPI network

From: Systematic analysis of ovarian cancer platinum-resistance mechanisms via text mining

NodeDescriptionDegree
TP53tumor protein p5356
HSP90AA1heat shock protein 90 alpha family class A member 141
ESR1estrogen receptor 140
AKT1AKT serine/threonine kinase 139
BRCA1BRCA1, DNA repair associated35
EGFRepidermal growth factor receptor34
CTNNB1catenin beta 131
CASP3caspase 330
HDAC1histone deacetylase 128
MAPK1mitogen-activated protein kinase 126
STAT3signal transducer and activator of transcription 326
MAPK8mitogen-activated protein kinase 825
SP1Sp1 transcription factor24
GSK3Bglycogen synthase kinase 3 beta23
CDKN1Acyclin dependent kinase inhibitor 1A23
PARP1poly (ADP-ribose) polymerase 122
BCL2BCL2, apoptosis regulator21
CASP8caspase 821
  1. All edges are treated as undirected. The degree of each node is calculated with CytoNCA, a plugin for Cytoscape