Table 1 Methylation analysis of hub genes in TCGA ovarian cancer. Negative correlations were found between TNF, ESR1, MUC1, CD44, PPP2R5C, PTEN, UBB and FOXO1 mRNA levels and methylation levels
From: Integrated analysis of gene expression and DNA methylation profiles in ovarian cancer
Gene | correlations of methylation level and mRNA level (cBioportal) |
|---|---|
TNF | Spearman: − 0.38(p = 2.16e-18) |
Pearson: − 0.38(p = 7.38e-18) | |
UBC | Spearman: 0.01(p = 0.799) |
Pearson: 0.04(p = 0.353) | |
SRC | No data |
ESR1 | Spearman: − 0.24(p = 1.13e-7) |
Pearson: −0.24(p = 1.04e-7) | |
CDK1 | No data |
PECAM1 | No data |
CXCR4 | Spearman: −0.05(p = 0.263) |
Pearson: −0.05(p = 0.257) | |
MUC1 | Spearman: − 0.13(p = 3.288e-3) |
Pearson: − 0.34(p = 9.48e-15) | |
IKBKG | No data |
BDNF | Spearman: −0.04(p = 0.435) |
Pearson: 0.03(p = 0.516) | |
CDC42 | Spearman: −0.09(p = 0.0469) |
Pearson: − 0.08(p = 0.0702) | |
CD44 | Spearman: − 0.22(p = 5.88e-7) |
Pearson: − 0.22(p = 8.34e-7) | |
PPP2R5C | Spearman: − 0.20(p = 1.194e-5) |
Pearson: − 0.13(p = 4.291e-3) | |
PTEN | Spearman: − 0.18(p = 5.541e-5) |
Pearson: − 0.23(p = 3.32e-7) | |
UBB | Spearman: − 0.69(p = 6.66e-70) |
Pearson: − 0.81(p = 1.76e-116) | |
BMP2 | Spearman: − 0.00(p = 0.944) |
Pearson: −0.11(p = 0.0150) | |
FOXO1 | Spearman: − 0.16(p = 4.634e-4) |
Pearson: − 0.17(p = 1.385e-4) | |
KLHL2 | No data |